Analysis Tools
vision/eye
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• length is reduced by about 1/3 compared to controls at 1 month of age
• outer segments become progressively shorter with age
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• progressive degeneration beginning at 1 month of age with loss of most rods by 6 months
• raising mice in complete darkness does not affect the rate of degeneration
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• by 6 months of age most rods are lost with only about 3 - 4 nuclei per row compared to 10 - 11 in wild-type mice
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• a-wave amplitude is 3-fold smaller than in wild-type mice but 5-fold larger than in Gnat1tm1Clma homozygous mice
• while maximal b-wave amplitude is similar to wild-type mice the half-saturating tight intensity for b-wave is about 2300-fold higher
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• the flash strength needed to half-maximally activate individual rods is about 70-fold brighter than that for wild-type rods
• the amplification constant is about 24-fold smaller than that of wild-type mice
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nervous system
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• length is reduced by about 1/3 compared to controls at 1 month of age
• outer segments become progressively shorter with age
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• progressive degeneration beginning at 1 month of age with loss of most rods by 6 months
• raising mice in complete darkness does not affect the rate of degeneration
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• by 6 months of age most rods are lost with only about 3 - 4 nuclei per row compared to 10 - 11 in wild-type mice
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