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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Mlh1tm1Wed
targeted mutation 1, Winfried Edelmann
MGI:3783409
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Mlh1tm1Wed/Mlh1tm1Wed involves: 129/Sv * C57BL/6J * SJL MGI:3783421


Genotype
MGI:3783421
hm1
Allelic
Composition
Mlh1tm1Wed/Mlh1tm1Wed
Genetic
Background
involves: 129/Sv * C57BL/6J * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mlh1tm1Wed mutation (0 available); any Mlh1 mutation (44 available)
phenotype observed in females
phenotype observed in males
N normal phenotype

Mlh1tm1Wed/Mlh1tm1Wed mouse testes show spermatogenic failure at or before metaphase of the first meiotic division

mortality/aging
• 50% of mice die by 30 weeks of age and all mice are dead by 64 weeks of age

reproductive system
• seminiferous tubules are severely depleted of spermatogenic cells
• sperm cells exhibit aberrant spindle configuration and premature chromosome separation during late pachytene and diplotene
• crossing-over foci are reduced 20% to 77% compared to in wild-type mice
• meiosis is arrested at metaphase I and become apoptotic
• sperm cells exhibit aberrant spindle configuration during late pachytene and diplotene

neoplasm
• 34 of 49 mice develop T and B cell lymphomas, 16 mice develop intestinal tumors (11 adenocarcinomas and 7 adenomas) and 4 mice develop squamous basal cell carcinoma of the skin
• 4 of 49 mice develop squamous basal cell carcinoma of the skin
• 34 of 49 mice develop T and B cell lymphomas

integument
• 4 of 49 mice develop squamous basal cell carcinoma of the skin

cellular
• seminiferous tubules are severely depleted of spermatogenic cells
• sperm cells exhibit aberrant spindle configuration and premature chromosome separation during late pachytene and diplotene
• crossing-over foci are reduced 20% to 77% compared to in wild-type mice
• meiosis is arrested at metaphase I and become apoptotic
• sperm cells exhibit aberrant spindle configuration during late pachytene and diplotene





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last database update
12/10/2024
MGI 6.24
The Jackson Laboratory