Phenotypes associated with this allele

• Allele Symbol: Oca2^p-4Btlr
• Allele Name: pink-eyed dilution 4 Bruce Beutler
• Allele ID: MGI:3783466
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Oca2^p-4Btlr/Oca2^p-4Btlr	C57BL/6J-Oca2^p-4Btlr	MGI:3783467

Genotype
MGI:3783467

hm1

• Allelic Composition: Oca2^p-4Btlr/Oca2^p-4Btlr
• Genetic Background: C57BL/6J-Oca2^p-4Btlr

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

pigmentation

diluted coat color ( J:133624 )

ocular albinism ( J:133624 )

vision/eye

ocular albinism ( J:133624 )

immune system

immune system phenotype ( J:133624 )

N • charbon homozygotes have a normal immune response to infection by mouse cytomegalovirus (MCMV)

N • natural killer (NK) cells of homozygous mutant mice exhibit normal in vivo kiling of target MHC class 1-deficient cells

N • homozygous mutant NK cells exhibit normal degranulation in vitro upon antibody stimulation of Ly49H or NKp46 receptors, stimulation by PMA ionomycin

N • intracellular production of IFN-alpha by mutant NK cells after PMA ionomycin stimulation is normal

N • homozygous mutant NK cells exhibit normal degranulation in vitro upon incubation with YAC-1 cells, in contrast to the failure of Oca2^p-3Btlr mutant NK cells to do so

increased susceptibility to bacterial infection ( J:133624 )

• 75% of homozygous mutant vs. 100% of wild-type mice survive infection by Listeria monocytogenes

• despite charbon mutants' reduced survival of L. monocytogenes infection, they produce normal amounts of cytokines and clear the bacteria from the liver as well as do wild-type mice

integument

diluted coat color ( J:133624 )