Phenotypes associated with this allele

• Allele Symbol: Rspo2^tm1Hoka
• Allele Name: targeted mutation 1, Hitoshi Okamoto
• Allele ID: MGI:3783769
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Rspo2^tm1Hoka/Rspo2^tm1Hoka	involves: C57BL/6 * CBA	MGI:3784871

Genotype
MGI:3784871

hm1

• Allelic Composition: Rspo2^tm1Hoka/Rspo2^tm1Hoka
• Genetic Background: involves: C57BL/6 * CBA

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

perinatal lethality, complete penetrance ( J:133600 )

• all die at birth

limbs/digits/tail

abnormal autopod morphology ( J:133600 )

• in at least one case a cleft foot is seen on the hind limbs

abnormal digit morphology ( J:133600 )

• forepaw digits are abnormally shaped and lack nail structures at E18.5

• on the hindpaws, in some cases the digits are not complete while in others only a single digit lacking cartilage is present

abnormal phalanx morphology ( J:133600 )

• defects are seen in the distal phalanges of the forepaws

abnormal forelimb morphology ( J:133600 )

• misshapen

• however, cartilage position is similar to wild-type controls at E14.5

abnormal forelimb zeugopod morphology ( J:133600 )

• in at least one case the hindlimb has only one zeugopod component (lacks fibula and has only 1 digit)

abnormal hindlimb morphology ( J:133600 )

• defects in the hindlimbs are more severe than those in the forelimbs although the penetrance and type of defects seen are variable

absent fibula ( J:133600 )

• in at least one case

abnormal limb development ( J:133600 )

• dermal pads are absent on the dorsal surface, but pads are present on the ventral surface

abnormal apical ectodermal ridge morphology ( J:133600 )

• poorly formed with abnormal expression of marker genes indicating expansion of expression of dorsal-specific markers

embryo

abnormal apical ectodermal ridge morphology ( J:133600 )

• poorly formed with abnormal expression of marker genes indicating expansion of expression of dorsal-specific markers

skeleton

abnormal phalanx morphology ( J:133600 )

• defects are seen in the distal phalanges of the forepaws

absent fibula ( J:133600 )

• in at least one case