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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Tg(Cryaa-AKR1B1)222Smch
transgene insertion 222, Stephen SM Chung
MGI:3783832
Summary 5 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cx1
Galk1tm1Stb/Galk1tm1Stb
Tg(Cryaa-AKR1B1)222Smch/0
involves: 129S6/SvEvTac * C57BL * CBA MGI:3784035
cx2
SordC57BL/Lia/SordC57BL/Lia
Tg(Cryaa-AKR1B1)222Smch/Tg(Cryaa-AKR1B1)222Smch
involves: C57BL * CBA MGI:3783848
cx3
SordC57BL/Lia/Sord+
Tg(Cryaa-AKR1B1)222Smch/0
involves: C57BL * CBA MGI:3783861
tg4
Tg(Cryaa-AKR1B1)222Smch/Tg(Cryaa-AKR1B1)222Smch involves: C57BL * CBA MGI:3783846
tg5
Tg(Cryaa-AKR1B1)222Smch/0 involves: C57BL * CBA MGI:3783847


Genotype
MGI:3784035
cx1
Allelic
Composition
Galk1tm1Stb/Galk1tm1Stb
Tg(Cryaa-AKR1B1)222Smch/0
Genetic
Background
involves: 129S6/SvEvTac * C57BL * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Galk1tm1Stb mutation (1 available); any Galk1 mutation (7 available)
Tg(Cryaa-AKR1B1)222Smch mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
vision/eye
• mice develop cataracts in absence of high galactose diet; cataract formation is detected at P0 on nomral or 40% glucose diet
• cataracts are detected as vacuoles at the periphery of the lens

homeostasis/metabolism
• at P0, lenses have high levels of galactitol relative to controls




Genotype
MGI:3783848
cx2
Allelic
Composition
SordC57BL/Lia/SordC57BL/Lia
Tg(Cryaa-AKR1B1)222Smch/Tg(Cryaa-AKR1B1)222Smch
Genetic
Background
involves: C57BL * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
SordC57BL/Lia mutation (0 available); any Sord mutation (21 available)
Tg(Cryaa-AKR1B1)222Smch mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
vision/eye
• mice injected with streptozotocin are susceptible to diabetic cataract formation, while non-transgenic SorD-deficient mice do not develop cataracts

homeostasis/metabolism
• mice injected with streptozotocin exhibit higher accumulation of sorbitol in the lens than wild-type beginning at 1 week after diabetes development




Genotype
MGI:3783861
cx3
Allelic
Composition
SordC57BL/Lia/Sord+
Tg(Cryaa-AKR1B1)222Smch/0
Genetic
Background
involves: C57BL * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
SordC57BL/Lia mutation (0 available); any Sord mutation (21 available)
Tg(Cryaa-AKR1B1)222Smch mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
homeostasis/metabolism
• mice injected with streptozotocin exhibit higher accumulation of sorbitol in the lens than wild-type beginning at 1 week after diabetes development




Genotype
MGI:3783846
tg4
Allelic
Composition
Tg(Cryaa-AKR1B1)222Smch/Tg(Cryaa-AKR1B1)222Smch
Genetic
Background
involves: C57BL * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
phenotype observed in females
phenotype observed in males
N normal phenotype
vision/eye
• mice injected with streptozotocin are susceptible to diabetic cataract formation more, but not as rapidly as galactosemic mice




Genotype
MGI:3783847
tg5
Allelic
Composition
Tg(Cryaa-AKR1B1)222Smch/0
Genetic
Background
involves: C57BL * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
phenotype observed in females
phenotype observed in males
N normal phenotype
vision/eye
N
• mice induced to become diabetic with streptozotocin injection do not develop cataracts
• 3-week old mice fed a 50% galactose diet, cataracts develop in transgenic animals, but not in non-transgenic mice; stages of cataract development reached correlates with level of transgene expression

homeostasis/metabolism





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last database update
11/05/2024
MGI 6.24
The Jackson Laboratory