Analysis Tools|
Allele Symbol Allele Name Allele ID |
Tg(Cryaa-AKR1B1)222Smch transgene insertion 222, Stephen SM Chung MGI:3783832 |
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| Summary |
5 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• mice develop cataracts in absence of high galactose diet; cataract formation is detected at P0 on nomral or 40% glucose diet
• cataracts are detected as vacuoles at the periphery of the lens
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• at P0, lenses have high levels of galactitol relative to controls
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• mice injected with streptozotocin are susceptible to diabetic cataract formation, while non-transgenic SorD-deficient mice do not develop cataracts
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• mice injected with streptozotocin exhibit higher accumulation of sorbitol in the lens than wild-type beginning at 1 week after diabetes development
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• mice injected with streptozotocin exhibit higher accumulation of sorbitol in the lens than wild-type beginning at 1 week after diabetes development
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
| N |
• mice induced to become diabetic with streptozotocin injection do not develop cataracts
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• 3-week old mice fed a 50% galactose diet, cataracts develop in transgenic animals, but not in non-transgenic mice; stages of cataract development reached correlates with level of transgene expression
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 12/10/2024 MGI 6.24 |
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