Analysis Tools|
Allele Symbol Allele Name Allele ID |
Tg(Cryaa-AKR1B1)648Smch transgene insertion 648, Stephen SM Chung MGI:3783833 |
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| Summary |
6 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• mice develop cataracts in absence of high galactose diet; cataract formation is detected at P0 on nomral or 40% glucose diet
• cataracts are detected as vacuoles at the periphery of the lens
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• at P0, lenses have high levels of galactitol relative to controls
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• mice injected with streptozotocin are susceptible to diabetic cataract formation, while non-transgenic SorD-deficient mice do not develop cataracts
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• mice injected with streptozotocin exhibit higher accumulation of sorbitol in the lens than wild-type beginning at 1 week after diabetes development
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• mice injected with streptozotocin are susceptible to diabetic cataract formation, while non-transgenic SorD-deficient mice do not develop cataracts
|
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• mice injected with streptozotocin exhibit higher accumulation of sorbitol in the lens than wild-type beginning at 1 week after diabetes development
|
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|
| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
|
• mice injected with streptozotocin exhibit higher accumulation of sorbitol in the lens than wild-type beginning at 1 week after diabetes development
|
|
• mice injected with streptozotocin are susceptible to diabetic cataract formation, while non-transgenic SorD-deficient mice do not develop cataracts
|
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|
| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
|
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
|
• mice injected with streptozotocin are susceptible to diabetic cataract formation, but cataracts do not develop as rapidly as in galactosemic transgenic mice
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• mice injected with streptozotocin exhibit higher accumulation of sorbitol in the lens than wild-type beginning at 1 week after diabetes development
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 09/24/2024 MGI 6.24 |
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