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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Tg(Cryaa-AKR1B1)648Smch
transgene insertion 648, Stephen SM Chung
MGI:3783833
Summary 6 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cx1
Galk1tm1Stb/Galk1tm1Stb
Tg(Cryaa-AKR1B1)648Smch/0
involves: 129S6/SvEvTac * C57BL * CBA MGI:3784037
cx2
SordC57BL/Lia/SordC57BL/Lia
Tg(Cryaa-AKR1B1)648Smch/Tg(Cryaa-AKR1B1)648Smch
involves: C57BL * CBA MGI:3783852
cx3
SordC57BL/Lia/SordC57BL/Lia
Tg(Cryaa-AKR1B1)648Smch/0
involves: C57BL * CBA MGI:3783853
cx4
SordC57BL/Lia/Sord+
Tg(Cryaa-AKR1B1)648Smch/0
involves: C57BL * CBA MGI:3783858
tg5
Tg(Cryaa-AKR1B1)648Smch/Tg(Cryaa-AKR1B1)648Smch involves: C57BL * CBA MGI:3783850
tg6
Tg(Cryaa-AKR1B1)648Smch/0 involves: C57BL * CBA MGI:3783849


Genotype
MGI:3784037
cx1
Allelic
Composition
Galk1tm1Stb/Galk1tm1Stb
Tg(Cryaa-AKR1B1)648Smch/0
Genetic
Background
involves: 129S6/SvEvTac * C57BL * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Galk1tm1Stb mutation (1 available); any Galk1 mutation (7 available)
Tg(Cryaa-AKR1B1)648Smch mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
vision/eye
• mice develop cataracts in absence of high galactose diet; cataract formation is detected at P0 on nomral or 40% glucose diet
• cataracts are detected as vacuoles at the periphery of the lens

homeostasis/metabolism
• at P0, lenses have high levels of galactitol relative to controls




Genotype
MGI:3783852
cx2
Allelic
Composition
SordC57BL/Lia/SordC57BL/Lia
Tg(Cryaa-AKR1B1)648Smch/Tg(Cryaa-AKR1B1)648Smch
Genetic
Background
involves: C57BL * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
SordC57BL/Lia mutation (0 available); any Sord mutation (21 available)
Tg(Cryaa-AKR1B1)648Smch mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
vision/eye
• mice injected with streptozotocin are susceptible to diabetic cataract formation, while non-transgenic SorD-deficient mice do not develop cataracts

homeostasis/metabolism
• mice injected with streptozotocin exhibit higher accumulation of sorbitol in the lens than wild-type beginning at 1 week after diabetes development




Genotype
MGI:3783853
cx3
Allelic
Composition
SordC57BL/Lia/SordC57BL/Lia
Tg(Cryaa-AKR1B1)648Smch/0
Genetic
Background
involves: C57BL * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
SordC57BL/Lia mutation (0 available); any Sord mutation (21 available)
Tg(Cryaa-AKR1B1)648Smch mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
vision/eye
• mice injected with streptozotocin are susceptible to diabetic cataract formation, while non-transgenic SorD-deficient mice do not develop cataracts

homeostasis/metabolism
• mice injected with streptozotocin exhibit higher accumulation of sorbitol in the lens than wild-type beginning at 1 week after diabetes development




Genotype
MGI:3783858
cx4
Allelic
Composition
SordC57BL/Lia/Sord+
Tg(Cryaa-AKR1B1)648Smch/0
Genetic
Background
involves: C57BL * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
SordC57BL/Lia mutation (0 available); any Sord mutation (21 available)
Tg(Cryaa-AKR1B1)648Smch mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
homeostasis/metabolism
• mice injected with streptozotocin exhibit higher accumulation of sorbitol in the lens than wild-type beginning at 1 week after diabetes development

vision/eye
• mice injected with streptozotocin are susceptible to diabetic cataract formation, while non-transgenic SorD-deficient mice do not develop cataracts




Genotype
MGI:3783850
tg5
Allelic
Composition
Tg(Cryaa-AKR1B1)648Smch/Tg(Cryaa-AKR1B1)648Smch
Genetic
Background
involves: C57BL * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
phenotype observed in females
phenotype observed in males
N normal phenotype
vision/eye
• mice injected with streptozotocin are susceptible to diabetic cataract formation more rapidly than heterozygous transgenic mice, but not as rapidly as galactosemic mice




Genotype
MGI:3783849
tg6
Allelic
Composition
Tg(Cryaa-AKR1B1)648Smch/0
Genetic
Background
involves: C57BL * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
phenotype observed in females
phenotype observed in males
N normal phenotype
vision/eye
• mice injected with streptozotocin are susceptible to diabetic cataract formation, but cataracts do not develop as rapidly as in galactosemic transgenic mice

homeostasis/metabolism
• mice injected with streptozotocin exhibit higher accumulation of sorbitol in the lens than wild-type beginning at 1 week after diabetes development





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last database update
12/10/2024
MGI 6.24
The Jackson Laboratory