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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Tg(GFAP-APOE_i4)22Hol
transgene insertion 22, David M Holtzman
MGI:3784296
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
cx1
 		Apoetm1Unc/Apoetm1Unc
Tg(GFAP-APOE_i4)22Hol/0 		B6.Cg-Apoetm1Unc Tg(GFAP-APOE_i4)22Hol MGI:3784306


Genotype
MGI:3784306
cx1
Allelic
Composition		 Apoetm1Unc/Apoetm1Unc
Tg(GFAP-APOE_i4)22Hol/0
Genetic
Background		 B6.Cg-Apoetm1Unc Tg(GFAP-APOE_i4)22Hol
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Apoetm1Unc mutation (33 available); any Apoe mutation (158 available)
Tg(GFAP-APOE_i4)22Hol mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
abnormal axon extension ( J:93487 )
• in vitro, neuron outgrowth is slower than in Tg(GFAP-APOE_i3)37Hol Apoetm1Unc/Apoetm1Unc neurons
• in vitro, neurite length is shorter than in Tg(GFAP-APOE_i3)37Hol Apoetm1Unc/Apoetm1Unc neurons

cellular
abnormal axon extension ( J:93487 )
• in vitro, neuron outgrowth is slower than in Tg(GFAP-APOE_i3)37Hol Apoetm1Unc/Apoetm1Unc neurons
• in vitro, neurite length is shorter than in Tg(GFAP-APOE_i3)37Hol Apoetm1Unc/Apoetm1Unc neurons




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory