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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Tg(Eno2-APP*751)10Cord
transgene insertion 10, Barbara Cordell
MGI:3784388
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cx1
 		Apoetm1Unc/Apoetm1Unc
Tg(Eno2-APP*751)10Cord/0 		involves: 129P2/OlaHsd * C57BL/6 MGI:3784391
cx2
 		Apoetm1Unc/Apoetm1Unc
Tg(Eno2-APP*751)10Cord/0
Cdh18Tg(GFAP-APOE_i4)1Hol/0 		involves: 129P2/OlaHsd * C57BL/6 * CBA MGI:3784389
cx3
 		Apoetm1Unc/Apoetm1Unc
Tg(Eno2-APP*751)10Cord/0
Tg(GFAP-APOE_i3)37Hol/0 		involves: 129P2/OlaHsd * C57BL/6 * CBA MGI:3784390


Genotype
MGI:3784391
cx1
Allelic
Composition		 Apoetm1Unc/Apoetm1Unc
Tg(Eno2-APP*751)10Cord/0
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Apoetm1Unc mutation (33 available); any Apoe mutation (158 available)
Tg(Eno2-APP*751)10Cord mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
homeostasis/metabolism
increased cerebral infarct size ( J:133156 )
• compared to in Apoetm1Unc homozygotes, Tg(Eno2-APP*751)10Cord Tg(GFAP-APOE_i4)1Hol Apoetm1Unc/Apoetm1Unc mice and Tg(Eno2-APP*751)10Cord Tg(GFAP-APOE*4)1Hol Apoetm1Unc/Apoetm1Unc

nervous system
increased cerebral infarct size ( J:133156 )
• compared to in Apoetm1Unc homozygotes, Tg(Eno2-APP*751)10Cord Tg(GFAP-APOE_i4)1Hol Apoetm1Unc/Apoetm1Unc mice and Tg(Eno2-APP*751)10Cord Tg(GFAP-APOE*4)1Hol Apoetm1Unc/Apoetm1Unc
gliosis ( J:133156 )
• mice exhibit more severe microgliosis following middle cerebral artery occlusion compared to Tg(Eno2-APP*751)10Cord Tg(GFAP-APOE_i4)1Hol Apoetm1Unc/Apoetm1Unc mice and Tg(Eno2-APP*751)10Cord Tg(GFAP-APOE*4)1Hol Apoetm1Unc/Apoetm1Unc mice




Genotype
MGI:3784389
cx2
Allelic
Composition		 Apoetm1Unc/Apoetm1Unc
Tg(Eno2-APP*751)10Cord/0
Cdh18Tg(GFAP-APOE_i4)1Hol/0
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Apoetm1Unc mutation (33 available); any Apoe mutation (158 available)
Cdh18Tg(GFAP-APOE_i4)1Hol mutation (1 available); any Cdh18 mutation (56 available)
Tg(Eno2-APP*751)10Cord mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
homeostasis/metabolism
decreased cerebral infarct size ( J:133156 )
• compared to in Tg(Eno2-APP*751)10Cord Apoetm1Unc/Apoetm1Unc mice

nervous system
decreased cerebral infarct size ( J:133156 )
• compared to in Tg(Eno2-APP*751)10Cord Apoetm1Unc/Apoetm1Unc mice
gliosis ( J:133156 )
• mice exhibit less severe microgliosis following medial cerebral artery occlusion compared to Tg(Eno2-APP*751)10Cord Apoetm1Unc/Apoetm1Unc mice




Genotype
MGI:3784390
cx3
Allelic
Composition		 Apoetm1Unc/Apoetm1Unc
Tg(Eno2-APP*751)10Cord/0
Tg(GFAP-APOE_i3)37Hol/0
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Apoetm1Unc mutation (33 available); any Apoe mutation (158 available)
Tg(Eno2-APP*751)10Cord mutation (0 available)
Tg(GFAP-APOE_i3)37Hol mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
homeostasis/metabolism
decreased cerebral infarct size ( J:133156 )
• compared to in Tg(Eno2-APP*751)10Cord Apoetm1Unc/Apoetm1Unc mice

nervous system
decreased cerebral infarct size ( J:133156 )
• compared to in Tg(Eno2-APP*751)10Cord Apoetm1Unc/Apoetm1Unc mice
gliosis ( J:133156 )
• mice exhibit less severe microgliosis following medial cerebral artery occlusion compared to Tg(Eno2-APP*751)10Cord Apoetm1Unc/Apoetm1Unc mice




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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory