About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Wdr1Gt(XN462)Byg
gene trap XN462, BayGenomics
MGI:3784953
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Wdr1Gt(XN462)Byg/Wdr1Gt(XN462)Byg involves: 129P2/OlaHsd MGI:3785511
ht2
 		Wdr1Gt(XN462)Byg/Wdr1rede involves: 129P2/OlaHsd * C57BL/6 MGI:3785510


Genotype
MGI:3785511
hm1
Allelic
Composition		 Wdr1Gt(XN462)Byg/Wdr1Gt(XN462)Byg
Genetic
Background		 involves: 129P2/OlaHsd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Wdr1Gt(XN462)Byg mutation (0 available); any Wdr1 mutation (41 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging




Genotype
MGI:3785510
ht2
Allelic
Composition		 Wdr1Gt(XN462)Byg/Wdr1rede
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Wdr1Gt(XN462)Byg mutation (0 available); any Wdr1 mutation (41 available)
Wdr1rede mutation (0 available); any Wdr1 mutation (41 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
postnatal lethality, incomplete penetrance ( J:134092 )
• mice die between 3 and 6 weeks of age

growth/size/body
decreased body size ( J:134092 )
• mice exhibit runting by 3 weeks of age compared to wild-type littermates

immune system
ear inflammation ( J:134092 )
• spontaneous inflammatory lesions occur on the outside portions of the ear by 3-6 weeks of age
• inflammatory lesions are more severe than in Wdr1rede homozygotes
skin inflammation ( J:134092 )
• mice have severe inflammation characterized by pustular lesions on the lower ventum
• inflammatory lesions are more severe than in Wdr1rede homozygotes

hearing/vestibular/ear
ear inflammation ( J:134092 )
• spontaneous inflammatory lesions occur on the outside portions of the ear by 3-6 weeks of age
• inflammatory lesions are more severe than in Wdr1rede homozygotes

hematopoietic system
thrombocytopenia ( J:134092 )
• three week old mice have 6-fold less platelets per liter of blood compared to wild-type littermates

integument
skin inflammation ( J:134092 )
• mice have severe inflammation characterized by pustular lesions on the lower ventum
• inflammatory lesions are more severe than in Wdr1rede homozygotes




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory