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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Wdr1Gt(XN462)Byg
gene trap XN462, BayGenomics
MGI:3784953
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Wdr1Gt(XN462)Byg/Wdr1Gt(XN462)Byg involves: 129P2/OlaHsd MGI:3785511
ht2
 		Wdr1Gt(XN462)Byg/Wdr1rede involves: 129P2/OlaHsd * C57BL/6 MGI:3785510


Genotype
MGI:3785511
hm1
Allelic
Composition		 Wdr1Gt(XN462)Byg/Wdr1Gt(XN462)Byg
Genetic
Background		 involves: 129P2/OlaHsd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Wdr1Gt(XN462)Byg mutation (0 available); any Wdr1 mutation (41 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging




Genotype
MGI:3785510
ht2
Allelic
Composition		 Wdr1Gt(XN462)Byg/Wdr1rede
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Wdr1Gt(XN462)Byg mutation (0 available); any Wdr1 mutation (41 available)
Wdr1rede mutation (0 available); any Wdr1 mutation (41 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
postnatal lethality, incomplete penetrance ( J:134092 )
• mice die between 3 and 6 weeks of age

growth/size/body
decreased body size ( J:134092 )
• mice exhibit runting by 3 weeks of age compared to wild-type littermates

immune system
ear inflammation ( J:134092 )
• inflammatory lesions are more severe than in Wdr1rede homozygotes
• spontaneous inflammatory lesions occur on the outside portions of the ear by 3-6 weeks of age
skin inflammation ( J:134092 )
• mice have severe inflammation characterized by pustular lesions on the lower ventum
• inflammatory lesions are more severe than in Wdr1rede homozygotes

hearing/vestibular/ear
ear inflammation ( J:134092 )
• spontaneous inflammatory lesions occur on the outside portions of the ear by 3-6 weeks of age
• inflammatory lesions are more severe than in Wdr1rede homozygotes

hematopoietic system
thrombocytopenia ( J:134092 )
• three week old mice have 6-fold less platelets per liter of blood compared to wild-type littermates

integument
skin inflammation ( J:134092 )
• mice have severe inflammation characterized by pustular lesions on the lower ventum
• inflammatory lesions are more severe than in Wdr1rede homozygotes




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory