Phenotypes associated with this allele

• Allele Symbol: Mmp14^m1Btlr
• Allele Name: mutation 1 Bruce Beutler
• Allele ID: MGI:3784968
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Mmp14^m1Btlr/Mmp14^m1Btlr	C57BL/6J-Mmp14^m1Btlr	MGI:3784969

Genotype
MGI:3784969

hm1

• Allelic Composition: Mmp14^m1Btlr/Mmp14^m1Btlr
• Genetic Background: C57BL/6J-Mmp14^m1Btlr

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:133626 )

• mice homozygous for this mutation live, on average, approximately 3 months

prenatal lethality, incomplete penetrance ( J:133626 )

• crosses between mice heterozygous for this mutation produce only about half the expected number of homozygous pups

growth/size/body

short snout ( J:133626 )

• homozygous cartoon mice exhibit shortened snouts

abnormal postnatal growth/weight/body size ( J:133626 )

• the physical growth/development of homozygotes is retarded or arrested at a young age

decreased body weight ( J:133626 )

• the average body weight of homoygous mutants at 7 weeks of age is 7.75 +/- 2.38 g, versus 20.56 +/- 2.38 g for their wild-type littermates

reproductive system

infertility ( J:133626 )

• homozygous mutant mice do not breed

craniofacial

decreased cranium height ( J:133626 )

• homozygous cartoon mice exhibit shortened heads

short snout ( J:133626 )

• homozygous cartoon mice exhibit shortened snouts

skeleton

decreased cranium height ( J:133626 )

• homozygous cartoon mice exhibit shortened heads

vision/eye

macrophthalmia ( J:133626 )

• the eyes of homozygous cartoon mice appear very large