All Phenotypes Lepr<Db-Btlr> MGI Mouse

About Help FAQ

Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Lepr^Db-Btlr
diabetes Bruce Beutler
MGI:3784988

Summary

2 genotypes

Allelic Composition	Lepr^Db-Btlr/Lepr^Db-Btlr
Genetic Background	C57BL/6J-Lepr^Db-Btlr

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lepr^Db-Btlr mutation (1 available); any Lepr mutation (122 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

growth/size/body

obese ( J:133632 )

• mice homozygous for this mutation are massively obese

homeostasis/metabolism

hyperglycemia ( J:133632 )

• homozygous mutant mice are diabetic

reproductive system

infertility ( J:133632 )

• homozygous mutant mice usually are sterile

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
obesity		DOID:9970	OMIM:601665	J:133632

Allelic Composition	Lepr^Db-Btlr/Lepr⁺
Genetic Background	C57BL/6J-Lepr^Db-Btlr

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lepr^Db-Btlr mutation (1 available); any Lepr mutation (122 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

growth/size/body

increased body weight ( J:133632 )

• mice heterozygous for this mutation are heavier than wild-type controls

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24