Phenotypes associated with this allele

• Allele Symbol: Igsf9^tm1Kln
• Allele Name: targeted mutation 1, Rudiger Klein
• Allele ID: MGI:3784989
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Igsf9^tm1Kln/Igsf9^tm1Kln	involves: 129P2/OlaHsd * C57BL/6	MGI:3795435
hm2	Igsf9^tm1Kln/Igsf9^tm1Kln	involves: 129P2/OlaHsd * C57BL/6 * CD-1	MGI:3795436

Genotype
MGI:3795435

hm1

• Allelic Composition: Igsf9^tm1Kln/Igsf9^tm1Kln
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

nervous system phenotype ( J:133898 , J:209586 )

N • extensive characterization of the dendritic structures of hippocampal neurons reveals no differences compared to wild-type mice (J:133898)

N • normal basal synaptic transmission and plasticity and unaltered excitatory synapse/spine density (J:209586)

increased susceptibility to pharmacologically induced seizures ( J:209586 )

• latency to PTZ-induced seizure is reduced by 36%, incidence of seizures is increased (52% compared to 36% in controls) and severity of induced seizures is increased compared to controls

abnormal synapse morphology ( J:209586 )

• decrease in the number of inhibitory synapses in the subicular stratum radiatum region

• numbers of inhibitory synapses are significantly reduced in cultured hippocampal neurons

decreased miniature inhibitory postsynaptic current frequency ( J:209586 )

• reduced mIPSC and sIPSC frequencies but not amplitudes in pyramidal neurons from mice at age P15-P20

• reduction in mIPSC frequency is more severe in younger mice (P5-P6)

behavior/neurological

increased susceptibility to pharmacologically induced seizures ( J:209586 )

• latency to PTZ-induced seizure is reduced by 36%, incidence of seizures is increased (52% compared to 36% in controls) and severity of induced seizures is increased compared to controls

Genotype
MGI:3795436

hm2

• Allelic Composition: Igsf9^tm1Kln/Igsf9^tm1Kln
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CD-1

normal phenotype

no abnormal phenotype detected ( J:133898 )

• mice are viable and fertile and do not show any obvious abnormalities

• extensive characterization of the dendritic structures of hippocampal neurons reveals no differences compared to wild-type mice