All Phenotypes Psca<tm1Witt> MGI Mouse

About Help FAQ

Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Psca^tm1Witt
targeted mutation 1, Owen N Witte
MGI:3784994

Summary

3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Psca^tm1Witt/Psca^tm1Witt	involves: 129/Sv * C57BL/6	MGI:3795481
cx2	Psca^tm1Witt/Psca^tm1Witt Tg(TRAMP)8247Ng/0	involves: 129/Sv * C57BL/6	MGI:3795482
cx3	Psca^tm1Witt/Psca⁺ Tg(TRAMP)8247Ng/0	involves: 129/Sv * C57BL/6	MGI:3795484

Allelic Composition	Psca^tm1Witt/Psca^tm1Witt
Genetic Background	involves: 129/Sv * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Psca^tm1Witt mutation (1 available); any Psca mutation (13 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

normal phenotype

no abnormal phenotype detected ( J:133908 )

• mice are viable, fertile, and aged mice develop tumors at the same rate as control mice

• extensive analysis revealed no difference in the size, structure, and regenerative capabilities of the prostrate

• there are no significant increases in prostrate adenocarcinomas or primary epithelial tumors after sub-lethal gamma irradiation compared to control mice

Allelic Composition	Psca^tm1Witt/Psca^tm1Witt Tg(TRAMP)8247Ng/0
Genetic Background	involves: 129/Sv * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Psca^tm1Witt mutation (1 available); any Psca mutation (13 available)
Tg(TRAMP)8247Ng mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

neoplasm

increased prostate gland tumor incidence ( J:133908 )

• mice are moribund with prostrate tumors on average at 28.6 weeks of age

• intraepithelial neoplasia and adenocarcinomas at different stages of differentiation are observed in the prostrate

• there is a increased incidence of metastasis compared to mice that carry just the transgene (56.5% compared to 33%)

increased prostate gland adenocarcinoma incidence ( J:133908 )

increased prostate intraepithelial neoplasia incidence ( J:133908 )

endocrine/exocrine glands

increased prostate gland tumor incidence ( J:133908 )

• mice are moribund with prostrate tumors on average at 28.6 weeks of age

• intraepithelial neoplasia and adenocarcinomas at different stages of differentiation are observed in the prostrate

• there is a increased incidence of metastasis compared to mice that carry just the transgene (56.5% compared to 33%)

increased prostate gland adenocarcinoma incidence ( J:133908 )

increased prostate intraepithelial neoplasia incidence ( J:133908 )

reproductive system

increased prostate gland tumor incidence ( J:133908 )

• mice are moribund with prostrate tumors on average at 28.6 weeks of age

• intraepithelial neoplasia and adenocarcinomas at different stages of differentiation are observed in the prostrate

• there is a increased incidence of metastasis compared to mice that carry just the transgene (56.5% compared to 33%)

increased prostate gland adenocarcinoma incidence ( J:133908 )

increased prostate intraepithelial neoplasia incidence ( J:133908 )

Allelic Composition	Psca^tm1Witt/Psca⁺ Tg(TRAMP)8247Ng/0
Genetic Background	involves: 129/Sv * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Psca^tm1Witt mutation (1 available); any Psca mutation (13 available)
Tg(TRAMP)8247Ng mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

neoplasm

increased prostate gland tumor incidence ( J:133908 )

• mice are moribund with prostrate tumors on average at 34.4 weeks of age

• intraepithelial neoplasia and adenocarcinomas at different stages of differentiation are observed in the prostrate

• there is a increased incidence of metastasis compared to mice that carry just the transgene

increased prostate gland adenocarcinoma incidence ( J:133908 )

increased prostate intraepithelial neoplasia incidence ( J:133908 )

reproductive system

increased prostate gland tumor incidence ( J:133908 )

• mice are moribund with prostrate tumors on average at 34.4 weeks of age

• intraepithelial neoplasia and adenocarcinomas at different stages of differentiation are observed in the prostrate

• there is a increased incidence of metastasis compared to mice that carry just the transgene

increased prostate gland adenocarcinoma incidence ( J:133908 )

increased prostate intraepithelial neoplasia incidence ( J:133908 )

endocrine/exocrine glands

increased prostate gland tumor incidence ( J:133908 )

• mice are moribund with prostrate tumors on average at 34.4 weeks of age

• intraepithelial neoplasia and adenocarcinomas at different stages of differentiation are observed in the prostrate

• there is a increased incidence of metastasis compared to mice that carry just the transgene

increased prostate gland adenocarcinoma incidence ( J:133908 )

increased prostate intraepithelial neoplasia incidence ( J:133908 )

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 10/29/2024 MGI 6.24