All Phenotypes Psca<tm1Witt> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Psca^tm1Witt
targeted mutation 1, Owen N Witte
MGI:3784994

Summary

3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Psca^tm1Witt/Psca^tm1Witt	involves: 129/Sv * C57BL/6	MGI:3795481
cx2	Psca^tm1Witt/Psca^tm1Witt Tg(TRAMP)8247Ng/0	involves: 129/Sv * C57BL/6	MGI:3795482
cx3	Psca^tm1Witt/Psca⁺ Tg(TRAMP)8247Ng/0	involves: 129/Sv * C57BL/6	MGI:3795484

Allelic Composition	Psca^tm1Witt/Psca^tm1Witt
Genetic Background	involves: 129/Sv * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Psca^tm1Witt mutation (1 available); any Psca mutation (13 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

normal phenotype

no abnormal phenotype detected ( J:133908 )

• mice are viable, fertile, and aged mice develop tumors at the same rate as control mice

• extensive analysis revealed no difference in the size, structure, and regenerative capabilities of the prostrate

• there are no significant increases in prostrate adenocarcinomas or primary epithelial tumors after sub-lethal gamma irradiation compared to control mice

Allelic Composition	Psca^tm1Witt/Psca^tm1Witt Tg(TRAMP)8247Ng/0
Genetic Background	involves: 129/Sv * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Psca^tm1Witt mutation (1 available); any Psca mutation (13 available)
Tg(TRAMP)8247Ng mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

neoplasm

increased prostate gland tumor incidence ( J:133908 )

• mice are moribund with prostrate tumors on average at 28.6 weeks of age

• intraepithelial neoplasia and adenocarcinomas at different stages of differentiation are observed in the prostrate

• there is a increased incidence of metastasis compared to mice that carry just the transgene (56.5% compared to 33%)

increased prostate gland adenocarcinoma incidence ( J:133908 )

increased prostate intraepithelial neoplasia incidence ( J:133908 )

endocrine/exocrine glands

increased prostate gland tumor incidence ( J:133908 )

• mice are moribund with prostrate tumors on average at 28.6 weeks of age

• intraepithelial neoplasia and adenocarcinomas at different stages of differentiation are observed in the prostrate

• there is a increased incidence of metastasis compared to mice that carry just the transgene (56.5% compared to 33%)

increased prostate gland adenocarcinoma incidence ( J:133908 )

increased prostate intraepithelial neoplasia incidence ( J:133908 )

reproductive system

increased prostate gland tumor incidence ( J:133908 )

• mice are moribund with prostrate tumors on average at 28.6 weeks of age

• intraepithelial neoplasia and adenocarcinomas at different stages of differentiation are observed in the prostrate

• there is a increased incidence of metastasis compared to mice that carry just the transgene (56.5% compared to 33%)

increased prostate gland adenocarcinoma incidence ( J:133908 )

increased prostate intraepithelial neoplasia incidence ( J:133908 )

Allelic Composition	Psca^tm1Witt/Psca⁺ Tg(TRAMP)8247Ng/0
Genetic Background	involves: 129/Sv * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Psca^tm1Witt mutation (1 available); any Psca mutation (13 available)
Tg(TRAMP)8247Ng mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

neoplasm

increased prostate gland tumor incidence ( J:133908 )

• mice are moribund with prostrate tumors on average at 34.4 weeks of age

• intraepithelial neoplasia and adenocarcinomas at different stages of differentiation are observed in the prostrate

• there is a increased incidence of metastasis compared to mice that carry just the transgene

increased prostate gland adenocarcinoma incidence ( J:133908 )

increased prostate intraepithelial neoplasia incidence ( J:133908 )

reproductive system

increased prostate gland tumor incidence ( J:133908 )

• mice are moribund with prostrate tumors on average at 34.4 weeks of age

• intraepithelial neoplasia and adenocarcinomas at different stages of differentiation are observed in the prostrate

• there is a increased incidence of metastasis compared to mice that carry just the transgene

increased prostate gland adenocarcinoma incidence ( J:133908 )

increased prostate intraepithelial neoplasia incidence ( J:133908 )

endocrine/exocrine glands

increased prostate gland tumor incidence ( J:133908 )

• mice are moribund with prostrate tumors on average at 34.4 weeks of age

• intraepithelial neoplasia and adenocarcinomas at different stages of differentiation are observed in the prostrate

• there is a increased incidence of metastasis compared to mice that carry just the transgene

increased prostate gland adenocarcinoma incidence ( J:133908 )

increased prostate intraepithelial neoplasia incidence ( J:133908 )

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