Phenotypes associated with this allele

• Allele Symbol: Tg(Ttn-Ighmbp2)45Cx
• Allele Name: transgene insertion 45, Gregory A Cox
• Allele ID: MGI:3785076
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cx1	Ighmbp2^nmd-2J/Ighmbp2^nmd-2J Tg(Ttn-Ighmbp2)45Cx/?	involves: C57BL/6J * C57BLKS/J	MGI:3785080
cx2	Ighmbp2^nmd-2J/Ighmbp2^nmd-2J Tg(Eno2-Ighmbp2)17Cx/? Tg(Ttn-Ighmbp2)45Cx/?	involves: C57BL/6J * C57BLKS/J	MGI:3785263

Genotype
MGI:3785080

cx1

• Allelic Composition: Ighmbp2^nmd-2J/Ighmbp2^nmd-2J; Tg(Ttn-Ighmbp2)45Cx/?
• Genetic Background: involves: C57BL/6J * C57BLKS/J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:102748 )

• lifespan is longer than that of nmd-2J mutants but shorter than that of the wild-type controls and falls partway between the two points

nervous system

motor neuron degeneration ( J:102748 )

• severe skeletal muscle neurogenic atrophy

muscle

muscle degeneration ( J:102748 )

• resulting from the spinal motor neuron degeneration

behavior/neurological

abnormal food intake ( J:102748 )

dysphagia ( J:102748 )

• difficulty in mastication or deglutition

cardiovascular system

cardiovascular system phenotype ( J:102748 )

N • mean ventricular free-wall thickness is normal

digestive/alimentary system

dysphagia ( J:102748 )

• difficulty in mastication or deglutition

enlarged esophagus ( J:102748 )

• susceptible to mega-esophagus

growth/size/body

enlarged esophagus ( J:102748 )

• susceptible to mega-esophagus

weight loss ( J:102748 )

• the presence of the transgene does not rescue the weight loss found in nmd-2J homozygotes

Genotype
MGI:3785263

cx2

• Allelic Composition: Ighmbp2^nmd-2J/Ighmbp2^nmd-2J; Tg(Eno2-Ighmbp2)17Cx/?; Tg(Ttn-Ighmbp2)45Cx/?
• Genetic Background: involves: C57BL/6J * C57BLKS/J

cardiovascular system

increased heart weight ( J:102748 )

• increased heart weight proportionally distributed throughout all 4 chambers, but aside from this the presence of both transgenes rescues nmd-2J homozygotes to a wild-type phenotype including no cardiomyopathy

growth/size/body

increased heart weight ( J:102748 )

• increased heart weight proportionally distributed throughout all 4 chambers, but aside from this the presence of both transgenes rescues nmd-2J homozygotes to a wild-type phenotype including no cardiomyopathy