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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Elanetm1Link
targeted mutation 1, David C Link
MGI:3785264
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Elanetm1Link/Elanetm1Link involves: 129X1/SvJ * C57BL/6 MGI:3785267
cx2
 		Csf3rtm2Link/Csf3r+
Elanetm1Link/Elane+ 		involves: 129X1/SvJ * C57BL/6 MGI:3785268


Genotype
MGI:3785267
hm1
Allelic
Composition		 Elanetm1Link/Elanetm1Link
Genetic
Background		 involves: 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Elanetm1Link mutation (0 available); any Elane mutation (25 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
hematopoietic system phenotype ( J:131496 )
N
• unlike severe congenital neutropenia patients with this allele, mice exhibit normal granulopoiesis, neutrophil counts, neutrophil survival in serum deprived media, granulocyte colony-stimulating factor (G-CSF) responsiveness, cyclophosphamide treatment recovery, and do not develop leukemia

normal phenotype
no abnormal phenotype detected ( J:131496 )
• mice are grossly indistinguishable from wild-type mice with normal growth, development and fertility

immune system
immune system phenotype ( J:131496 )
N
• unlike severe congenital neutropenia patients with this allele, mice exhibit normal granulopoiesis, neutrophil counts, neutrophil survival in serum deprived media, granulocyte colony-stimulating factor (G-CSF) responsiveness, cyclophosphamide treatment recovery, and do not develop leukemia




Genotype
MGI:3785268
cx2
Allelic
Composition		 Csf3rtm2Link/Csf3r+
Elanetm1Link/Elane+
Genetic
Background		 involves: 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Csf3rtm2Link mutation (0 available); any Csf3r mutation (42 available)
Elanetm1Link mutation (0 available); any Elane mutation (25 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
hematopoietic system phenotype ( J:131496 )
N
• mice exhibit normal neutrophil counts

immune system
immune system phenotype ( J:131496 )
N
• mice exhibit normal neutrophil counts




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory