Phenotypes associated with this allele

• Allele Symbol: Tcrg^tm1Dhr
• Allele Name: targeted mutation 1, David Raulet
• Allele ID: MGI:3785561
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Tcrg^tm1Dhr/Tcrg^tm1Dhr	involves: 129	MGI:3795459

Genotype
MGI:3795459

hm1

• Allelic Composition: Tcrg^tm1Dhr/Tcrg^tm1Dhr
• Genetic Background: involves: 129

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

abnormal T cell receptor gamma chain V-J recombination ( J:133974 )

• mutant allele contains 2 Vgamma2 gene segments, one in the normal upstream position and the second at the downstream position normally occupied by Vgamma3

• the downstream Vgamma2 gene segment rearranged four to five more times frequently than the upstream gene segment in E14 fetal thymocytes

• the total level of Vgamma2 rearrangements is four fold higher in E14 thymocytes compared to wild-type embryos

• in adult mice, there is about a 2-fold preference in rearrangement of the upstream Vgamma2 gene segment compared to the downstream gene segment, which is much smaller than the 25-fold preference for Vgamma2 rearrangements over the downstream Vgamma3 gene segment observed in wild-type mice

• germline transcripts are found at the same level as in wild-type embyros in E14 thymocytes but there is a 2.2-fold reduction in germline transcripts of the downstream Vgamma2 gene segment in adult mice

hematopoietic system

abnormal T cell receptor gamma chain V-J recombination ( J:133974 )

• mutant allele contains 2 Vgamma2 gene segments, one in the normal upstream position and the second at the downstream position normally occupied by Vgamma3

• the downstream Vgamma2 gene segment rearranged four to five more times frequently than the upstream gene segment in E14 fetal thymocytes

• the total level of Vgamma2 rearrangements is four fold higher in E14 thymocytes compared to wild-type embryos

• in adult mice, there is about a 2-fold preference in rearrangement of the upstream Vgamma2 gene segment compared to the downstream gene segment, which is much smaller than the 25-fold preference for Vgamma2 rearrangements over the downstream Vgamma3 gene segment observed in wild-type mice

• germline transcripts are found at the same level as in wild-type embyros in E14 thymocytes but there is a 2.2-fold reduction in germline transcripts of the downstream Vgamma2 gene segment in adult mice