Phenotypes associated with this allele

• Allele Symbol: Tg(Ins2-E3)1Dvs
• Allele Name: transgene insertion 1, David V Serreze
• Allele ID: MGI:3785598
• Summary: 3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cx1	H2^b/H2^d Tg(Ins2-E3)1Dvs/0	involves: BALB/c * C57BL/6 * DBA/2J	MGI:3785747
tg2	Tg(Ins2-E3)1Dvs/?	involves: C57BL/6 * DBA/2J	MGI:3785749
tg3	Tg(Ins2-E3)1Dvs/?	NOD.Cg-Tg(Ins2-E3)1Dvs	MGI:3785602

Genotype
MGI:3785747

cx1

• Allelic Composition: H2^b/H2^d; Tg(Ins2-E3)1Dvs/0
• Genetic Background: involves: BALB/c * C57BL/6 * DBA/2J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

increased length of allograft survival ( J:109763 )

• when transferred into BALB/c hosts, but not C57BL/6 hosts, pancreatic islets from H2 survive much longer than non-transgenic pancreatic islets

Genotype
MGI:3785749

tg2

• Allelic Composition: Tg(Ins2-E3)1Dvs/?
• Genetic Background: involves: C57BL/6 * DBA/2J

normal phenotype

no abnormal phenotype detected ( J:109763 )

Genotype
MGI:3785602

tg3

• Allelic Composition: Tg(Ins2-E3)1Dvs/?
• Genetic Background: NOD.Cg-Tg(Ins2-E3)1Dvs

immune system

decreased susceptibility to autoimmune diabetes ( J:68996 )

• decreased incidence and delayed onset of diabetes relative to the NOD background control

• at 14 weeks of age the insulitis score is lower than in NOD controls, and splenocytes transferred from 6 week old transgenic donors into NOD mice homozygous for the scid mutation results in a lower incidence of hyperglycemia in the host than those recieving non-transgenic NOD splenocytes

• delayed onset of diabetes after transferring splenocytes from pre-diabetic or diabetic NOD donors