Phenotypes associated with this allele

• Allele Symbol: Ltb4r2^tm1Tksh
• Allele Name: targeted mutation 1, Takao Schimizu
• Allele ID: MGI:3785609
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Ltb4r2^tm1Tksh/Ltb4r2^tm1Tksh	B6.Cg-Ltb4r2^tm1Tksh	MGI:5517588
hm2	Ltb4r2^tm1Tksh/Ltb4r2^tm1Tksh	C.Cg-Ltb4r2^tm1Tksh	MGI:5517541

Genotype
MGI:5517588

hm1

• Allelic Composition: Ltb4r2^tm1Tksh/Ltb4r2^tm1Tksh
• Genetic Background: B6.Cg-Ltb4r2^tm1Tksh

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

decreased susceptibility to type I hypersensitivity reaction ( J:197334 )

• in a model of IgE antigen-dependent passive cutaneous anaphylaxis, mice exhibit decreased dye extravasation (a measure of edema) compared with wild-type mice

homeostasis/metabolism

edema ( J:197334 )

• in a model of IgE antigen-dependent passive cutaneous anaphylaxis, mice exhibit decreased dye extravasation (a measure of edema) compared with wild-type mice

Genotype
MGI:5517541

hm2

• Allelic Composition: Ltb4r2^tm1Tksh/Ltb4r2^tm1Tksh
• Genetic Background: C.Cg-Ltb4r2^tm1Tksh

immune system

abnormal mast cell physiology ( J:133998 )

• bone marrow-derived mast cells fail to migrate in response to 12-12(S)-hydroxyheptadeca-5Z, 8E, 10E-trienoic acid (12-HHT) unlike wild-type cells

• however, bone marrow-derived mast cells exhibit normal migration in response to LTB4 and stem cell factor (SCF)

hematopoietic system

abnormal mast cell physiology ( J:133998 )

• bone marrow-derived mast cells fail to migrate in response to 12-12(S)-hydroxyheptadeca-5Z, 8E, 10E-trienoic acid (12-HHT) unlike wild-type cells

• however, bone marrow-derived mast cells exhibit normal migration in response to LTB4 and stem cell factor (SCF)