All Phenotypes Ppp1r3a<tm2Adpr> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Ppp1r3a^tm2Adpr
targeted mutation 2, Anna A DePaoli-Roach
MGI:3785748

Summary

2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Ppp1r3a^tm2Adpr/Ppp1r3a^tm2Adpr	involves: 129S6/SvEvTac * C57BL/6J	MGI:3789680
ht2	Ppp1r3a^tm2Adpr/Ppp1r3a⁺	involves: 129S6/SvEvTac * C57BL/6J	MGI:3789681

Allelic Composition	Ppp1r3a^tm2Adpr/Ppp1r3a^tm2Adpr
Genetic Background	involves: 129S6/SvEvTac * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ppp1r3a^tm2Adpr mutation (0 available); any Ppp1r3a mutation (58 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

homeostasis/metabolism

abnormal glycogen homeostasis ( J:134157 )

• 68% reduction in glycogen synthase to glucose-6-phosphate ratio reflecting a reduction in phosphorylation and activity of glycogen synthase

• however, whole body glycogen synthesis and glycolysis, muscle specific insulin-stimulated glycogen synthesis and glucose and insulin tolerances are all similar to controls

decreased skeletal muscle glycogen level ( J:134157 )

• 55% reduction in skeletal muscle glycogen content compared to wild-type controls

muscle

decreased skeletal muscle glycogen level ( J:134157 )

• 55% reduction in skeletal muscle glycogen content compared to wild-type controls

Allelic Composition	Ppp1r3a^tm2Adpr/Ppp1r3a⁺
Genetic Background	involves: 129S6/SvEvTac * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ppp1r3a^tm2Adpr mutation (0 available); any Ppp1r3a mutation (58 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

homeostasis/metabolism

abnormal glycogen homeostasis ( J:134157 )

• 45% reduction in glycogen synthase to glucose-6-phosphate ratio reflecting a reduction in phosphorylation and activity of glycogen synthase

• however, whole body glycogen synthesis and glycolysis, muscle specific insulin-stimulated glycogen synthesis and glucose and insulin tolerances are all similar to controls

decreased skeletal muscle glycogen level ( J:134157 )

• 40% reduction in skeletal muscle glycogen content compared to wild-type controls

muscle

decreased skeletal muscle glycogen level ( J:134157 )

• 40% reduction in skeletal muscle glycogen content compared to wild-type controls

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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