Analysis Tools
behavior/neurological
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• adult mice injected with tamoxifen at P7 show deficits in spatial working memory in a working memory test (delayed nonmatched to place task, DNMTP) compared to adult controls (wild-type and vehicle-treated transgenic animals)
• with tamoxifen injection at adulthood (6 hours prior to testing), transgenic mice show no difference from adult wild-type
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• in forced-swim test, adult mice treated with tamoxifen at P7 display depressive-like behavior as demonstrated by shorter latencies between floating episodes than those of control mice
• with tamoxifen injection at adulthood (6 hours prior to testing), transgenic mice show no difference from adult controls
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• in a social choice paradigm, adult mice treated with tamoxifen at P7 spend significantly more time in empty chamber away from stimulus mouse than in stimulus mouse chamber compared to controls
• with tamoxifen injection at adulthood (6 hours prior to testing), transgenic mice show no difference from adult controls
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nervous system
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• reduced dendritic complexity in adult mice treated with tamoxifen at P7
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• numbers of branch points and intersections in hippocampal neurons in adult mice treated with tamoxifen at P7 are reduced compared to controls;
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• adult mice treated with tamoxifen at P7 show reduced hippocampal synaptic input/output function compared to controls
• paired pulse facilitation and long term potentiation in mice treated at P7 are both normal indicating that presynaptic function and LTP are unaffected by transgenic protein expression
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Mouse Models of Human Disease |
DO ID | OMIM ID(s) | Ref(s) | |
| schizophrenia | DOID:5419 |
OMIM:181500 |
J:127235 | |
