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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Tg(CAG-IL1RN)2Cga
transgene insertion 2, Cem Gabay
MGI:3789049
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
cx1
 		Apoetm1Unc/Apoetm1Unc
Tg(CAG-IL1RN)2Cga/? 		involves: 129P2/OlaHsd * C57BL/6 * DBA/1 * FVB MGI:3789132


Genotype
MGI:3789132
cx1
Allelic
Composition		 Apoetm1Unc/Apoetm1Unc
Tg(CAG-IL1RN)2Cga/?
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6 * DBA/1 * FVB
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Apoetm1Unc mutation (33 available); any Apoe mutation (158 available)
Tg(CAG-IL1RN)2Cga mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cardiovascular system
decreased susceptibility to atherosclerosis ( J:132570 )
• atherosclerotic lesions in the aortic root are reduced by 40% relative to Apoetm1Unc single homozygotes
• 67% reduction in the descending aorta
• reduced susceptibility in the aortic arch

immune system
decreased circulating serum amyloid protein level ( J:132570 )
• reduced levels of serum Amyloid A

homeostasis/metabolism
decreased circulating serum amyloid protein level ( J:132570 )
• reduced levels of serum Amyloid A




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory