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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Pcsk5tm2Prat
targeted mutation 2, Annik Prat
MGI:3789183
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Meox2tm1(cre)Sor/Meox2+
Pcsk5tm2Prat/Pcsk5tm2.1Prat 		involves: 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ MGI:3797216
cn2
 		Meox2tm1(cre)Sor/0
Pcsk5tm2Prat/Pcsk5tm2.1Prat 		involves: 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ * C57BL/6 * SJL MGI:3796238


Genotype
MGI:3797216
cn1
Allelic
Composition		 Meox2tm1(cre)Sor/Meox2+
Pcsk5tm2Prat/Pcsk5tm2.1Prat
Genetic
Background		 involves: 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Meox2tm1(cre)Sor mutation (3 available); any Meox2 mutation (18 available)
Pcsk5tm2.1Prat mutation (0 available); any Pcsk5 mutation (96 available)
Pcsk5tm2Prat mutation (0 available); any Pcsk5 mutation (96 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cardiovascular system
vascular ring ( J:136243 )
• mice exhibit an aortic vascular ring
abnormal heart morphology ( J:136243 )
• cardiac malformations
dextrocardia ( J:136243 )
• dextroposition (one of four)

skeleton
abnormal skeleton morphology ( J:136243 )
• mice exhibit axial and appendicular skeletal defects similar to those in Pcsk5vcc homozygotes
abnormal vertebral column morphology ( J:136243 )
• mice exhibit a presacral mass protruding ventrally from the caudal end of the spinal cord and vertebral column in mice lacking a tail

digestive/alimentary system

limbs/digits/tail
short tail ( J:136243 )
• in some mice
absent tail ( J:136243 )
• in some mice

respiratory system
pulmonary hypoplasia ( J:136243 )
• in the left lung

renal/urinary system

nervous system
abnormal spinal cord morphology ( J:136243 )
• mice exhibit a presacral mass protruding ventrally from the caudal end of the spinal cord and vertebral column in mice lacking a tail

craniofacial

growth/size/body
abnormal palate morphology ( J:136243 )
• absent
omphalocele ( J:136243 )




Genotype
MGI:3796238
cn2
Allelic
Composition		 Meox2tm1(cre)Sor/0
Pcsk5tm2Prat/Pcsk5tm2.1Prat
Genetic
Background		 involves: 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ * C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Meox2tm1(cre)Sor mutation (3 available); any Meox2 mutation (18 available)
Pcsk5tm2.1Prat mutation (0 available); any Pcsk5 mutation (96 available)
Pcsk5tm2Prat mutation (0 available); any Pcsk5 mutation (96 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
neonatal lethality, complete penetrance ( J:134264 )
• embryoes that express the cre knock-in allele during development die at birth from respiratory distress

growth/size/body
decreased body size ( J:134264 )
• E18.5 embryos are smaller than controls

limbs/digits/tail
short tail ( J:134264 )
• E18.5 pups have shortened or absent tails
absent tail ( J:134264 )
• E18.5 pups have shortened or absent tails

respiratory system
atelectasis ( J:134264 )
• the airways and alveoli of E18.5 embryos are collapsed
respiratory failure ( J:134264 )
• pups die at birth from apparent respiratory failure

skeleton
abnormal sternocostal joint morphology ( J:134264 )
• 18.5 embryos have incomplete closure of the sternum
asymmetric sternocostal joints ( J:134264 )
• 18.5 embryos have an assymmetric fusion of the ribs to the sternum
increased rib number ( J:134264 )
• 14 of 15 embryos have one to three additional ribs attached to the sternum
vertebral transformation ( J:134264 )
• 10 of 15 embryos have 3 to 4 additional thoracic vertebrae, 8 lumbar vertebrae, and only three to nine sacral and caudal vertebrae
• none of the embryos have the normal complement of vertebraes
delayed bone ossification ( J:134264 )
• ossification is retarded namely in the mandibles, nasal bone, vertebrae and limbs

renal/urinary system
absent kidney ( J:134264 )
• all E18.5 embryos lack at least one kidney with only 1/6th of the mice having a normal kidney

digestive/alimentary system
herniated intestine ( J:134264 )
• most E18.5 embryos have abdominal herniations

cardiovascular system
hemorrhage ( J:134264 )
• subepidermal hemorrhages occur on the head or along the spine amongst the smallest 18.5 embryos




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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory