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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Tlx3tm1(cre)Qima
targeted mutation 1, Qiufu Ma
MGI:3789185
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Bhlhe22tm2.1Meg/Bhlhe22tm2.1Meg
Tlx3tm1(cre)Qima/Tlx3+ 		involves: 129 MGI:4440934
cn2
 		Gt(ROSA)26Sortm1(Smo/EYFP)Amc/Gt(ROSA)26Sortm1(Smo/EYFP)Amc
Tlx3tm1(cre)Qima/Tlx3+ 		involves: 129X1/SvJ MGI:3810319


Genotype
MGI:4440934
cn1
Allelic
Composition		 Bhlhe22tm2.1Meg/Bhlhe22tm2.1Meg
Tlx3tm1(cre)Qima/Tlx3+
Genetic
Background		 involves: 129
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bhlhe22tm2.1Meg mutation (0 available); any Bhlhe22 mutation (12 available)
Tlx3tm1(cre)Qima mutation (0 available); any Tlx3 mutation (14 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
behavior/neurological
behavior/neurological phenotype ( J:158273 )
N
• mice do not show skin lesions or heightened itch responses to pruritic agents

integument
integument phenotype ( J:158273 )
N
• mice do not show skin lesions in response to selective deletion in excitatory neurons in dorsal horn




Genotype
MGI:3810319
cn2
Allelic
Composition		 Gt(ROSA)26Sortm1(Smo/EYFP)Amc/Gt(ROSA)26Sortm1(Smo/EYFP)Amc
Tlx3tm1(cre)Qima/Tlx3+
Genetic
Background		 involves: 129X1/SvJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm1(Smo/EYFP)Amc mutation (1 available); any Gt(ROSA)26Sor mutation (993 available)
Tlx3tm1(cre)Qima mutation (0 available); any Tlx3 mutation (14 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
premature death ( J:139574 )
• mice survive 102 days

neoplasm
increased medulloblastoma incidence ( J:139574 )
• 40% of mice develop focal medulloblastomas and have a mean survival of 102 days

nervous system
increased medulloblastoma incidence ( J:139574 )
• 40% of mice develop focal medulloblastomas and have a mean survival of 102 days

Mouse Models of Human Disease
 DO ID OMIM ID(s) Ref(s)
medulloblastoma DOID:0050902 OMIM:155255
 J:139574




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory