All Phenotypes Tg(ACTB-Lama5)1Jhm MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Tg(ACTB-Lama5)1Jhm
transgene insertion 1, Jeffrey H Miner
MGI:3789283

Summary

1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
cx1	Lama2^dy-2J/Lama2^dy-2J Lama4^tm1Ktry/Lama4^tm1Ktry Tg(ACTB-Lama5)1Jhm/0	involves: 129X1/SvJ * C57BL/6 * WK/ReJ	MGI:3789290

Allelic Composition	Lama2^dy-2J/Lama2^dy-2J Lama4^tm1Ktry/Lama4^tm1Ktry Tg(ACTB-Lama5)1Jhm/0
Genetic Background	involves: 129X1/SvJ * C57BL/6 * WK/ReJ

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lama2^dy-2J mutation (1 available); any Lama2 mutation (177 available)
Lama4^tm1Ktry mutation (1 available); any Lama4 mutation (114 available)
Tg(ACTB-Lama5)1Jhm mutation (0 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

nervous system phenotype ( J:98086 )

N	• sorting and myelination in distal nerves are improved compared to in Lama2^dy-2J Lama4^tm1Blp homozygotes

behavior/neurological

behavior/neurological phenotype ( J:98086 )

N	• tremors and dyskinesia observed in Lama2^dy-2J Lama4^tm1Blp homozygotes are suppressed

cellular

abnormal basal lamina morphology ( J:98086 )

• promyelinating Schwann cells lack a basal lamina

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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