Phenotypes associated with this allele

• Allele Symbol: Tob2^tm1Tya
• Allele Name: targeted mutation 1, Tadashi Yamamoto
• Allele ID: MGI:3789484
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Tob2^tm1Tya/Tob2^tm1Tya	involves: 129S4/SvJae * C57BL/6	MGI:3807254

Genotype
MGI:3807254

hm1

• Allelic Composition: Tob2^tm1Tya/Tob2^tm1Tya
• Genetic Background: involves: 129S4/SvJae * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

skeleton

abnormal osteoclast differentiation ( J:134287 )

• fewer osteoclasts differentiate from cultured mutant bone marrow cells stimulated with an osteotropic factor than from stimulated wild-type bone marrow cells

increased osteoclast cell number ( J:134287 )

• proportion of bone surface covered with osteoclasts is 317% greater than in wild-type

abnormal osteoclast physiology ( J:134287 )

• eroded bone surface which is an indicator of osteoclast function is 199% greater than in wild-type

abnormal trabecular bone morphology ( J:134287 )

• bone volume/tissue volume is decreased compared to wild-type littermates

decreased bone mass ( J:134287 )

• bone mass is 62% of wild-type littermates at 9 months of age

osteoporosis ( J:134287 )

increased bone resorption ( J:134287 )

hematopoietic system

abnormal osteoclast differentiation ( J:134287 )

• fewer osteoclasts differentiate from cultured mutant bone marrow cells stimulated with an osteotropic factor than from stimulated wild-type bone marrow cells

increased osteoclast cell number ( J:134287 )

• proportion of bone surface covered with osteoclasts is 317% greater than in wild-type

abnormal osteoclast physiology ( J:134287 )

• eroded bone surface which is an indicator of osteoclast function is 199% greater than in wild-type

immune system

abnormal osteoclast differentiation ( J:134287 )

• fewer osteoclasts differentiate from cultured mutant bone marrow cells stimulated with an osteotropic factor than from stimulated wild-type bone marrow cells

increased osteoclast cell number ( J:134287 )

• proportion of bone surface covered with osteoclasts is 317% greater than in wild-type

abnormal osteoclast physiology ( J:134287 )

• eroded bone surface which is an indicator of osteoclast function is 199% greater than in wild-type

cellular

abnormal osteoclast differentiation ( J:134287 )

• fewer osteoclasts differentiate from cultured mutant bone marrow cells stimulated with an osteotropic factor than from stimulated wild-type bone marrow cells