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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Dclre1atm1Remo
targeted mutation 1, Robb E Moses
MGI:3789591
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Dclre1atm1Remo/Dclre1atm1Remo involves: 129X1/SvJ MGI:3804705
cx2
 		Dclre1atm1Remo/Dclre1atm1Remo
Fancd2tm1Hou/Fancd2tm1Hou 		involves: 129S4/SvJae * 129X1/SvJ * C57BL/6J MGI:3804706


Genotype
MGI:3804705
hm1
Allelic
Composition		 Dclre1atm1Remo/Dclre1atm1Remo
Genetic
Background		 involves: 129X1/SvJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dclre1atm1Remo mutation (1 available); any Dclre1a mutation (41 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cellular
abnormal chromosome morphology ( J:134461 )
• primary fibroblasts isolated from mice are 3.0-fold more sensitive to radial chromosome formation upon treatment with mitomycin C




Genotype
MGI:3804706
cx2
Allelic
Composition		 Dclre1atm1Remo/Dclre1atm1Remo
Fancd2tm1Hou/Fancd2tm1Hou
Genetic
Background		 involves: 129S4/SvJae * 129X1/SvJ * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dclre1atm1Remo mutation (1 available); any Dclre1a mutation (41 available)
Fancd2tm1Hou mutation (0 available); any Fancd2 mutation (82 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
perinatal lethality, incomplete penetrance ( J:134461 )
• 33% less double homozygotes are born than expected
• Background Sensitivity: the expected number of double homozygotes are observed when the breeding stock has a higher percentage of 129 background




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory