About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Dclre1atm1Remo
targeted mutation 1, Robb E Moses
MGI:3789591
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Dclre1atm1Remo/Dclre1atm1Remo involves: 129X1/SvJ MGI:3804705
cx2
 		Dclre1atm1Remo/Dclre1atm1Remo
Fancd2tm1Hou/Fancd2tm1Hou 		involves: 129S4/SvJae * 129X1/SvJ * C57BL/6J MGI:3804706


Genotype
MGI:3804705
hm1
Allelic
Composition		 Dclre1atm1Remo/Dclre1atm1Remo
Genetic
Background		 involves: 129X1/SvJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dclre1atm1Remo mutation (1 available); any Dclre1a mutation (41 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cellular
abnormal chromosome morphology ( J:134461 )
• primary fibroblasts isolated from mice are 3.0-fold more sensitive to radial chromosome formation upon treatment with mitomycin C




Genotype
MGI:3804706
cx2
Allelic
Composition		 Dclre1atm1Remo/Dclre1atm1Remo
Fancd2tm1Hou/Fancd2tm1Hou
Genetic
Background		 involves: 129S4/SvJae * 129X1/SvJ * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dclre1atm1Remo mutation (1 available); any Dclre1a mutation (41 available)
Fancd2tm1Hou mutation (0 available); any Fancd2 mutation (82 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
perinatal lethality, incomplete penetrance ( J:134461 )
• 33% less double homozygotes are born than expected
• Background Sensitivity: the expected number of double homozygotes are observed when the breeding stock has a higher percentage of 129 background




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory