Phenotypes associated with this allele

• Allele Symbol: Prkg1^tm1Meme
• Allele Name: targeted mutation 1, Michael E Mendelsohn
• Allele ID: MGI:3789972
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Prkg1^tm1Meme/Prkg1^tm1Meme	involves: 129S/SvEv	MGI:3789973

Genotype
MGI:3789973

hm1

• Allelic Composition: Prkg1^tm1Meme/Prkg1^tm1Meme
• Genetic Background: involves: 129S/SvEv

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cardiovascular system

increased systemic arterial blood pressure ( J:134634 )

salt-resistant hypertension ( J:134634 )

• develops by 10 - 12 weeks of age

increased mean systemic arterial blood pressure ( J:134634 )

increased systemic arterial diastolic blood pressure ( J:134634 )

increased systemic arterial systolic blood pressure ( J:134634 )

abnormal blood vessel physiology ( J:134634 )

• serum-stimulated freshly dispersed vascular smooth muscle cells show increased stress fiber formation and adopt a broader, spread morphology compared to wild-type cells

decreased vasodilation ( J:134634 )

• impaired nitric oxide-mediated relaxation and 8Br-cGMP-mediated endothelium independent relaxation in aortic rings

• impaired nitric oxide-mediated relaxation in resistance size arteries

renal/urinary system

renal/urinary system phenotype ( J:134634 )

N • despite hypertension, no abnormalities are detected in renal glomerular filtration rate, renal plasma flow, or blood urea nitrogen, serum creatinine, or serum electrolyte levels

muscle

decreased vasodilation ( J:134634 )

• impaired nitric oxide-mediated relaxation and 8Br-cGMP-mediated endothelium independent relaxation in aortic rings

• impaired nitric oxide-mediated relaxation in resistance size arteries