Analysis Tools
behavior/neurological
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• a fear conditioning task reveals that mice fail to remember the fear conditioning stimulus delivered 24 hours earlier
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• mice have increased length of whiskers resulting from less trimming by littermates
• when housed with with wild-type littermates, whisker length is normal
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• the mean number of social interactions that occur in a 10 minute span are reduced from 63.5 to 52.6
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nervous system
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• excess neuronal apoptosis occurs in the forebrain during the first two weeks of life
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• whole-brain parenchyma volume is reduced by 20% while ventricular volume is significantly increased
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• 5 month old mice have about a 20% reduction in brain weight compared to control mice
• differences in brain weight are first observed in 10 days after birth
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• neurons in the cerebral cortices are smaller and more tightly packed
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• neurons in the brain have fewer dendrtiic arborizations
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• mice have decreased reductions in startle response when subjected to pre-pulses of 76dB and 82dB
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growth/size/body
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• the mean body weight of 5 month old female mice is one gram less than age-matched wild-type mice
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cellular
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• excess neuronal apoptosis occurs in the forebrain during the first two weeks of life
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