All Phenotypes Tagln<tm1(PRKG1*)Hfm> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Tagln^{tm1(PRKG1*)Hfm}
targeted mutation 1, Franz Hofmann
MGI:3790077

Summary

1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
cx1	Prkg1^tm2.1Naw/Prkg1^tm2.1Naw Tagln^{tm1(PRKG1*)Hfm}/Tagln⁺	involves: 129S1/Sv * 129X1/SvJ	MGI:3797264

Allelic Composition	Prkg1^tm2.1Naw/Prkg1^tm2.1Naw Tagln^{tm1(PRKG1*)Hfm}/Tagln⁺
Genetic Background	involves: 129S1/Sv * 129X1/SvJ

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Prkg1^tm2.1Naw mutation (0 available); any Prkg1 mutation (60 available)
Tagln^{tm1(PRKG1*)Hfm} mutation (0 available); any Tagln mutation (28 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

premature death ( J:134928 )

• mice have a median survival time of 52 weeks

• this survival time is significantly longer than Prkg1^tm2.1Naw homozygote that do not carry the knock-in allele

reproductive system

reduced female fertility ( J:134928 )

• female mice have a reduced success rate of pregnancy

decreased litter size ( J:134928 )

• mice have slightly reduced litter size of 3 to 6 pups

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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