Phenotypes associated with this allele

• Allele Symbol: Tagln^{tm2(PRKG1*)Hfm}
• Allele Name: targeted mutation 2, Franz Hofmann
• Allele ID: MGI:3790081
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cx1	Prkg1^tm2.1Naw/Prkg1^tm2.1Naw Tagln^tm2(PRKG1*)Hfm/Tagln^+	involves: 129S1/Sv * 129X1/SvJ	MGI:3797265
cx2	Irag1^tm2.1Jens/Irag1^tm2.1Jens Tagln^tm2(PRKG1*)Hfm/Tagln^tm2(PRKG1*)Hfm	involves: 129S1/Sv * 129X1/SvJ	MGI:5292657

Genotype
MGI:3797265

cx1

• Allelic Composition: Prkg1^tm2.1Naw/Prkg1^tm2.1Naw; Tagln^{tm2(PRKG1*)Hfm}/Tagln⁺
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:134928 )

• mice have a median survival time of 52 weeks

• this survival time is significantly longer than Prkg1^tm2.1Naw homozygote that do not carry the knock-in allele

reproductive system

reduced female fertility ( J:134928 )

♀ • female mice have a reduced success rate of pregnancy

decreased litter size ( J:134928 )

• mice have slightly reduced litter size of 3 to 6 pups

Genotype
MGI:5292657

cx2

• Allelic Composition: Irag1^tm2.1Jens/Irag1^tm2.1Jens; Tagln^{tm2(PRKG1*)Hfm}/Tagln^{tm2(PRKG1*)Hfm}
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ

muscle

impaired muscle relaxation ( J:175887 )

• colon and vascular smooth muscle exhibit reduced cGMP-mediated relaxation compared with similarly treated wild-type smooth muscle