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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Fermt2tm1Ref
targeted mutation 1, Reinhard Fassler
MGI:3790102
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Fermt2tm1Ref/Fermt2tm1Ref Not Specified MGI:3797380


Genotype
MGI:3797380
hm1
Allelic
Composition
Fermt2tm1Ref/Fermt2tm1Ref
Genetic
Background
Not Specified
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fermt2tm1Ref mutation (0 available); any Fermt2 mutation (32 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• homozygote embryos are missing at E7.5
• 26% of embryos from heterozygote matings are misshapen and partially resorbed at E6.5

cellular
• embryonic stem cells barely adhere to the feeding cell layer or to dishes coated with extracellular matrix proteins

embryo
• about half of the embryonic bodies that form in culture have spotty basement membranes, detached endoderm, and eventually degenerate
• the half of embryonic bodies that survive in culture have poorly developed cavities with varying degrees of endoderm and epiblast detachment





Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
12/10/2024
MGI 6.24
The Jackson Laboratory