Phenotypes associated with this allele

• Allele Symbol: Fermt2^tm1Ref
• Allele Name: targeted mutation 1, Reinhard Fassler
• Allele ID: MGI:3790102
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Fermt2^tm1Ref/Fermt2^tm1Ref	Not Specified	MGI:3797380

Genotype
MGI:3797380

hm1

• Allelic Composition: Fermt2^tm1Ref/Fermt2^tm1Ref
• Genetic Background: Not Specified

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality between implantation and somite formation, complete penetrance ( J:134768 )

• homozygote embryos are missing at E7.5

• 26% of embryos from heterozygote matings are misshapen and partially resorbed at E6.5

cellular

abnormal cell adhesion ( J:134768 )

• embryonic stem cells barely adhere to the feeding cell layer or to dishes coated with extracellular matrix proteins

embryo

abnormal germ layer development ( J:134768 )

• about half of the embryonic bodies that form in culture have spotty basement membranes, detached endoderm, and eventually degenerate

abnormal embryonic epiblast morphology ( J:134768 )

• the half of embryonic bodies that survive in culture have poorly developed cavities with varying degrees of endoderm and epiblast detachment