All Phenotypes Lgr4<Gt(LST020)Byg> MGI Mouse

decreased survivor rate ( J:134299 )

• about 60% of mice die within the first day of birth

embryonic growth retardation ( J:134299 )

• embryos are retarded in growth

decreased body weight ( J:134299 )

• weight of mice on the day of birth is 60-70% that of littermate controls

increased incidence of corneal inflammation ( J:134299 )

• 10% of mice have inflammation in the cornea

abnormal anterior eye segment morphology ( J:134299 )

abnormal iridocorneal angle ( J:134299 )

• the iridocorneal angle is smaller to varying degrees in these mice

• in 12.5% of the mice, the corneal angle is completely closed due to adhesion of the iris to the cornea

abnormal canal of Schlemm morphology ( J:134299 )

• the Schlemm's canal is much smaller in both length and width

hypoplastic trabecular meshwork ( J:134299 )

• the trabecular meshworks are compressed and contain many fewer trabecular beams with smaller beam size

ciliary body hypoplasia ( J:134299 )

• the ciliary body is much smaller containing less folding and fewer cells

mydriasis ( J:134299 )

• mice have significantly larger pupils

iris hypoplasia ( J:134299 )

• the iris only contains a small layer of brown tissue around the cornea and is much thinner and shorter than in wild-type mice

iris stroma hypoplasia ( J:134299 )

• the stroma of the iris is smaller with 12-18 stromal cells present per pupil compared to 25-35 stromal cells present in wild-type pupils

• the thickness in the middle of the stroma is also dramatically reduced due to hypoplasia of smooth muscle cells that reside in the stroma

abnormal cornea morphology ( J:134299 )

cornea vascularization ( J:134299 )

• the majority of mice with opaque corneas also have vascularization

• 8% of all adult mice have cornea vascular pannus

anterior iris synechia ( J:134299 )

• in 12.5% of the mice, the corneal angle is completely closed due to adhesion of the iris to the cornea

abnormal cornea epithelium morphology ( J:134299 )

• cornea epithelial plugs exist in 16% of mice

• in addition, 8% of mice have lost their surface smoothness

decreased cornea epithelium thickness ( J:134299 )

• corneal epithelium is thinner than controls starting at 10 days of age with epithelial cells appearing shrunken and more compact

cornea epithelium hypoplasia ( J:134299 )

• cell proliferation and cell differentiation are significantly slower in these mice

decreased cornea thickness ( J:134299 )

• corneal epithelium is thinner than controls starting at 10 days of age with epithelial cells appearing shrunken and more compact

abnormal cornea stroma morphology ( J:134299 )

• the lamellar arrangement of collagen in cornea is disorganized with fibers crossing each other random

decreased cornea stroma thickness ( J:134299 )

• the cornea stroma of adult mice is significantly thinner

cornea deposits ( J:134299 )

• 10% of mice have cystic-like lesions present in the cornea

cornea opacity ( J:134299 )

• 40% of mice have opacity of the cornea

abnormal lens morphology ( J:134299 )

• the ratio of soluble to insoluble alphaA-crystalin is lower in these mice

disorganized secondary lens fibers ( J:134299 )

• lens fibers are disorganized and abnormally larger in the cortical zone of lens in mice with cataracts

cataract ( J:134299 )

• 26% of adult mice have cataracts with opacity ranging from total to partial

small lens ( J:134299 )

• in mice without len fiber anomalies, the lens size is significantly smaller than in controls

microphthalmia ( J:134299 )

• 75% of male mice that survive birth have a small eye phenotype

• 37% of female survivors have the small eye phenotype

abnormal retina morphology ( J:134299 )

retina ganglion cell degeneration ( J:134299 )

• there is a significant loss of ganglion cells in 10 of 24 mice over 6 months of age

thin retina inner nuclear layer ( J:134299 )

• the inner nuclear layer is thinned and disarranged in 10 of 24 mice over 6 months of age

disorganized retina inner nuclear layer ( J:134299 )