All Phenotypes Opn4<tm4(DTA)Saha> MGI Mouse

Phenotypes associated with this allele

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Opn4^tm4(DTA)Saha/Opn4^tm4(DTA)Saha	involves: 129 * C57BL/6	MGI:3797740
ht2	Opn4^tm4(DTA)Saha/Opn4⁺	involves: 129 * C57BL/6	MGI:3797741
ht3	Opn4^tm1Yau/Opn4^tm4(DTA)Saha	involves: 129 * C57BL/6	MGI:3797748

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

impaired pupillary reflex ( J:134780 )

• papillary light reflex is absent when exposed to light bright enough to cause 50% constriction in wild-type controls

• all mice have about a 50% decrease in papillary light reflex in response to high intensity light

abnormal visual pursuit ( J:134780 )

• there is a slight but significant decrease in the image-tracking reflex of these mice

abnormal locomotor circadian rhythm ( J:134780 )

• mouse activity occurs randomly over a 7-hour light/dark cycle while wild-type controls confine their activity to the dark phases

prolonged circadian behavior period ( J:134780 )

• mice have a significantly longer mean period of 23.8 hours under constant dark conditions compared to 23.3 for wild-type mice

• under constant light conditions mice maintain a mean period under 24 hours while wild-type mice extend their mean period to 25.5 hours

abnormal circadian behavior phase ( J:134780 )

• a light stimulus administered for 15 minutes fails to affect the phase onset of activity while wild-type mice shift phases by 1.66 hours

abnormal circardian behavior entrainment ( J:134780 )

• two-thirds of mice fail to synchronize when the light/dark cycle is shifted by six hours

• the other third show weak synchronization but do not form stable relationships to the light/dark cycle

nervous system

abnormal suprachiasmatic nucleus morphology ( J:134780 )

• very few fibers innervate the SCN from the retinal ganglion cells

abnormal retina ganglion cell morphology ( J:134780 )

• less than 3% of retinal ganglion cells expressing melanopsin are present compared to wild-type controls

• there are fewer fiber terminals from the retinal ganglion cells reach into the suprachiasmatic nucleus, the intergeniculate leaflet, and the olivary pretectal nucleus

vision/eye

impaired pupillary reflex ( J:134780 )

• papillary light reflex is absent when exposed to light bright enough to cause 50% constriction in wild-type controls

• all mice have about a 50% decrease in papillary light reflex in response to high intensity light

abnormal visual pursuit ( J:134780 )

• there is a slight but significant decrease in the image-tracking reflex of these mice

abnormal retina ganglion cell morphology ( J:134780 )

• less than 3% of retinal ganglion cells expressing melanopsin are present compared to wild-type controls

• there are fewer fiber terminals from the retinal ganglion cells reach into the suprachiasmatic nucleus, the intergeniculate leaflet, and the olivary pretectal nucleus

Allelic Composition	Opn4^tm4(DTA)Saha/Opn4⁺
Genetic Background	involves: 129 * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Opn4^tm4(DTA)Saha mutation (0 available); any Opn4 mutation (33 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

vision/eye

impaired pupillary reflex ( J:134780 )

• papillary light reflex is absent when exposed to light bright enough to cause 50% constriction in wild-type controls

• 3 of 9 mice have decreased papillary light reflex in response to high intensity light

abnormal retina ganglion cell morphology ( J:134780 )

• only 3.1% of retinal ganglion cells expressing melanopsin are present compared to wild-type controls

• the degree of ablation for melanopsin-containing retinal ganglion cells increases with age until they are virtually absent at one year of age

behavior/neurological

impaired pupillary reflex ( J:134780 )

• papillary light reflex is absent when exposed to light bright enough to cause 50% constriction in wild-type controls

• 3 of 9 mice have decreased papillary light reflex in response to high intensity light

nervous system

abnormal retina ganglion cell morphology ( J:134780 )

• only 3.1% of retinal ganglion cells expressing melanopsin are present compared to wild-type controls

• the degree of ablation for melanopsin-containing retinal ganglion cells increases with age until they are virtually absent at one year of age

Allelic Composition	Opn4^tm1Yau/Opn4^tm4(DTA)Saha
Genetic Background	involves: 129 * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Opn4^tm1Yau mutation (0 available); any Opn4 mutation (33 available)
Opn4^tm4(DTA)Saha mutation (0 available); any Opn4 mutation (33 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

vision/eye

abnormal retina ganglion cell morphology ( J:134780 )

• only 17.1% of retinal ganglion cells expressing melanopsin are present compared to wild-type controls

• there are fewer fiber terminals from the retinal ganglion cells reach into the suprachiasmatic nucleus, the intergeniculate leaflet, and the olivary pretectal nucleus

nervous system

abnormal suprachiasmatic nucleus morphology ( J:134780 )

• few fibers innervate the SCN from the retinal ganglion cells

abnormal retina ganglion cell morphology ( J:134780 )

• only 17.1% of retinal ganglion cells expressing melanopsin are present compared to wild-type controls

• there are fewer fiber terminals from the retinal ganglion cells reach into the suprachiasmatic nucleus, the intergeniculate leaflet, and the olivary pretectal nucleus

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