Phenotypes associated with this allele

• Allele Symbol: Masp1^tm1Tefu
• Allele Name: targeted mutation 1, Teizo Fujita
• Allele ID: MGI:3790322
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Masp1^tm1Tefu/Masp1^tm1Tefu	B6.129S4-Masp1^tm1Tefu	MGI:3798177

Genotype
MGI:3798177

hm1

• Allelic Composition: Masp1^tm1Tefu/Masp1^tm1Tefu
• Genetic Background: B6.129S4-Masp1^tm1Tefu

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

decreased survivor rate ( J:134537 )

• only 63 homozygous pups were born from heterozygote matings when the expected number was around 110

growth/size/body

decreased body weight ( J:134537 )

• mice are significantly smaller

• the average bodyweights of male mice are 16.8 grams compared to 20.8 grams for wild-type males

• female mice are also smaller with a mean weight of 14.8 grams compared to 17.9 grams

immune system

impaired complement alternative pathway ( J:177350 )

• mice treated with collagen antibodies do not exhibit C43 or C5a depositions compared unlike similarly treated wild-type mice

impaired lectin complement pathway ( J:134537 )

• activation of the lectin complement pathway is deficient in these mice

• C4 deposition from the sera of mice onto a mannose covered plate is much lower than from sera of wild-type mice

• likewise, C3 deposition from sera of mutant mice is also reduced