Phenotypes associated with this allele

• Allele Symbol: Abcc2^tm1Dgen
• Allele Name: targeted mutation 1, Deltagen
• Allele ID: MGI:3790671
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Abcc2^tm1Dgen/Abcc2^tm1Dgen	involves: 129P2/OlaHsd * C57BL/6	MGI:3804924

Genotype
MGI:3804924

hm1

• Allelic Composition: Abcc2^tm1Dgen/Abcc2^tm1Dgen
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

increased circulating bilirubin level ( J:134950 )

• total bilirubin levels were 5-fold higher in mutant mice

• 60% of total bilirubin was conjugated bilirubin, where as the level of conjugated bilirubin in serum of wild-type mice was undetectable

• level of direct bilirubin were 6.7-fold higher in mutant mice urine

increased circulating cholesterol level ( J:134950 )

• 1.5-fold higher in male mutant mice, but no significant changes was observed between female mutant mice and control mice

decreased circulating alkaline phosphatase level ( J:134950 )

• a slightly decreased alkaline phosphatase level

liver/biliary system

abnormal bile secretion ( J:134950 )

• decreased biliary secretion of dibromosulfphthalein administered intravenously

abnormal bile composition ( J:134950 )

• the biliary excretion rate of glutathione was 16-fold lower in mutant mice

• the biliary excretion rate of bilirubin glucuronides was 2-fold lower in mutant mice

abnormal liver physiology ( J:134950 )

• a 3-fold increase in glutathione level in mutant liver extracts