Phenotypes associated with this allele

• Allele Symbol: Dpysl4^tm1Ttq
• Allele Name: targeted mutation 1, Tam T Quach
• Allele ID: MGI:3790672
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Dpysl4^tm1Ttq/Dpysl4^tm1Ttq	involves: 129	MGI:3804907

Genotype
MGI:3804907

hm1

• Allelic Composition: Dpysl4^tm1Ttq/Dpysl4^tm1Ttq
• Genetic Background: involves: 129

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

abnormal hippocampus CA1 region morphology ( J:134800 )

• an outgrowth of thick dendrites (>2.5 micrometers) extend into and throughout the stratum oriens

• this results in about a 40-fold increase in the density of neurites found in the stratum oriens

• some neurons lack a typical thick apical dendrite projecting into the stratum radiatum and instead have a cluster of thin, short neuritis

abnormal hippocampus pyramidal cell layer ( J:134800 )

• 42% of neurons display tortuous/undulating apical dendrites compared to just 6% in WT mice

• there is also a decrease in the number of pyramidal cells bearing 4 basal somata stems, which leads to decreases of about 25% in basilar dendritic lengths

abnormal hippocampus pyramidal cell morphology ( J:134800 )

• dendrites from pyramidal neurons have an abnormal pattern with poor alignment and are wavier in appearance than the straight apical dendrites of wild-type mice

• the mean linearity index for apical dendrites is 1.3 +/- 0.05 compared to 1.06 +/- 0.01

• the number of branches on apical dendrites of CA1 pyramidal cells is decreased by about 25% for primary dendrites and by about 50% for secondary dendrites

• total dendritic length is also reduced by about a third

• lengths of mushroom and finger spines of pyramidal cells is significantly reduced

impaired synaptic plasticity ( J:134800 )

• there is a significant reduction in subsequent burst responses of the CA1 region of the hippocoampus with burst response numbers 2, 4, and 6 being 42%, 51%, and 43% of the initial response while subsequent responses of the wild-type hippocampus are similar to the initial response

reduced long-term potentiation ( J:134800 )

• there is a significant decrease of 60% in the magnitude of LTP in hippocampal slices prepared from area CA1

• there is also a significant reduction in subsequent burst responses with burst response numbers 2, 4, and 6 being 42%, 51%, and 43% of the initial response while subsequent responses of the wild-type hippocampus are similar to the initial response