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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Lin7ctm2Dsb
targeted mutation 2, David S Bredt
MGI:3790689
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Lin7ctm2Dsb/Lin7ctm2Dsb
Tg(Hoxb7-cre)13Amc/0 		involves: 129S1/Sv * 129X1/SvJ * C57BL/6 MGI:3804963
cn2
 		Lin7ctm2Dsb/Lin7ctm2Dsb
Tg(Pax3-cre)1Joe/0 		involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL MGI:3804964


Genotype
MGI:3804963
cn1
Allelic
Composition		 Lin7ctm2Dsb/Lin7ctm2Dsb
Tg(Hoxb7-cre)13Amc/0
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lin7ctm2Dsb mutation (0 available); any Lin7c mutation (17 available)
Tg(Hoxb7-cre)13Amc mutation (2 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
normal phenotype




Genotype
MGI:3804964
cn2
Allelic
Composition		 Lin7ctm2Dsb/Lin7ctm2Dsb
Tg(Pax3-cre)1Joe/0
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lin7ctm2Dsb mutation (0 available); any Lin7c mutation (17 available)
Tg(Pax3-cre)1Joe mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype

Lin7ctm2Dsb/Lin7ctm2Dsb Tg(Pax3-cre)1Joe kidney exhibits increased apoptosis

renal/urinary system
increased kidney apoptosis ( J:134806 )
• E14.5 kidneys have a 10-fold more apoptosis occurring within the renal capsule compared to controls
• this increased apoptosis is evident as early as E12.5
renal interstitial fibrosis ( J:134806 )
• is observed in adult kidneys with extracellular matrix proteins and fibroblasts evident
decreased kidney weight ( J:134806 )
• kidneys are about half the weight of wild-type kidney
dilated renal tubule ( J:134806 )
• adult kidneys display tubular dilation and dedifferentiation of the renal tubules

cellular
increased kidney apoptosis ( J:134806 )
• E14.5 kidneys have a 10-fold more apoptosis occurring within the renal capsule compared to controls
• this increased apoptosis is evident as early as E12.5




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/17/2024
MGI 6.24 		The Jackson Laboratory