Analysis Tools
growth/size/body
|
• males and females fed either a normal chow diet or a high-fat chow diet display slightly but significantly increased body weight, although over time, weight normalizes
• corticosterone replacement in mutants increases food intake and body weight
|
homeostasis/metabolism
|
• reduction in plasma corticosterone concentrations is seen as early as 3 weeks of age, with levels continuing to decrease over time
• mutants show an impairment in stress-induced corticosterone production
• injection of ACTH analog does not increase plasma corticosterone to the level of control mice, consistent with adrenal insufficiency
• corticosterone replacement in mutants increases food intake and body weight
|
|
• initially, mutants exhibit an elevation in serum leptin levels at 8 weeks of age, however by 18 weeks of age, they show lower serum leptin levels than controls but have an unchanged body weight
|
|
• glucose-stimulated insulin secretion is lower than in controls
|
|
• analysis of glucose-stimulated insulin secretion shows that although insulin secretion is lower, their blood glucose concentration is also lower than in controls
|
|
• initial elevation in serum glucose levels at 8 weeks of age
|
|
• old mutants perform better than controls during glucose tolerance tests
|
|
• old mutants show significantly increased insulin sensitivity during insulin tolerance tests than controls
|
endocrine/exocrine glands
|
• decrease in melanotroph numbers in the intermediate lobe of the pituitary, but do not see an obvious change in fur color or skin pigmentation
|
|
• glucose-stimulated insulin secretion is lower than in controls
|
adipose tissue
|
• at 18 weeks of age, mutants show reduced epigonadal fat-pad mass
|
behavior/neurological
polyphagia
(
J:134336
)
|
• significant hyperphagia at 8 weeks of age but not at 10 weeks of age
• corticosterone replacement in mutants increases food intake and body weight
|
nervous system
|
• decrease in melanotroph numbers in the intermediate lobe of the pituitary, but do not see an obvious change in fur color or skin pigmentation
|
