All Phenotypes Brca1<tm1Thl> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Brca1^tm1Thl
targeted mutation 1, Thomas Ludwig
MGI:3790741

Summary

7 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Brca1^tm1Thl/Brca1^tm1Thl	involves: 129 * C57BL/6J	MGI:3805030
cn2	Brca1^tm1Thl/Brca1^tm1Thl Wap^tm1(cre)Arge/0	involves: 129S1/Sv * C57BL/6J	MGI:3805033
cn3	Brca1^tm1Thl/Brca1^tm2Rjbr Kras^tm4Tyj/Kras⁺ Trp53^tm1Thl/Trp53^tm1Thl Tg(Pdx1-cre)6Tuv/0	involves: 129S4/SvJae * C57BL/6 * FVB/N	MGI:5494465
cn4	Brca1^tm1Thl/Brca1^tm3.1Rjbr Kras^tm4Tyj/Kras⁺ Trp53^tm1Thl/Trp53^tm1Thl Tg(Pdx1-cre)6Tuv/0	involves: 129S4/SvJae * C57BL/6 * FVB/N	MGI:5494462
cn5	Brca1^tm1Thl/Brca1^tm1Thl Kras^tm4Tyj/Kras⁺ Trp53^tm1Thl/Trp53^tm1Thl Tg(Pdx1-cre)6Tuv/0	involves: 129S4/SvJae * C57BL/6 * FVB/N	MGI:5494464
cn6	Brca1^tm1Arge/Brca1^tm1Thl Wap^tm1(cre)Arge/0	involves: 129S/SvEv * 129S1/Sv * C57BL/6J	MGI:3805032
cn7	Bard1^tm2Thl/Bard1^tm2Thl Brca1^tm1Thl/Brca1^tm1Thl Wap^tm1(cre)Arge/0	involves: 129/Sv * 129S1/Sv * C57BL/6J	MGI:3805035

Allelic Composition	Brca1^tm1Thl/Brca1^tm1Thl
Genetic Background	involves: 129 * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Brca1^tm1Thl mutation (1 available); any Brca1 mutation (114 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

normal phenotype

no abnormal phenotype detected ( J:134977 )

• mice are healthy, fertile, and have a normal lifespan

Allelic Composition	Brca1^tm1Thl/Brca1^tm1Thl Wap^tm1(cre)Arge/0
Genetic Background	involves: 129S1/Sv * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Brca1^tm1Thl mutation (1 available); any Brca1 mutation (114 available)
Wap^tm1(cre)Arge mutation (0 available); any Wap mutation (33 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

neoplasm

increased mammary adenocarcinoma incidence ( J:134977 )

• almost all female mice who have been pregnant at least once develop mammary tumors with a mean tumor free latency of 512 days

• majority of tumors are solid, do not express the estrogen receptor but are CK14 positive

• the majority of the tumors are Dunn type B adenocarcinomas with a medullary growth pattern that display variable necrosis and lack peripheral lymphocytic infiltrate

• carnicomas contain pleomorphic cells with numerous mitotic figures such as lagging chromosomes

• neoplasms often invade in a broad front and push towards the underlying pectoral muscle

• a small minority of tumors have sqaumous characteristics

• pre-cancerous neoplasia are also evident throughout the mammary gland

integument

increased mammary adenocarcinoma incidence ( J:134977 )

• almost all female mice who have been pregnant at least once develop mammary tumors with a mean tumor free latency of 512 days

• majority of tumors are solid, do not express the estrogen receptor but are CK14 positive

• the majority of the tumors are Dunn type B adenocarcinomas with a medullary growth pattern that display variable necrosis and lack peripheral lymphocytic infiltrate

• carnicomas contain pleomorphic cells with numerous mitotic figures such as lagging chromosomes

• neoplasms often invade in a broad front and push towards the underlying pectoral muscle

• a small minority of tumors have sqaumous characteristics

• pre-cancerous neoplasia are also evident throughout the mammary gland

endocrine/exocrine glands

increased mammary adenocarcinoma incidence ( J:134977 )

• almost all female mice who have been pregnant at least once develop mammary tumors with a mean tumor free latency of 512 days

• majority of tumors are solid, do not express the estrogen receptor but are CK14 positive

• the majority of the tumors are Dunn type B adenocarcinomas with a medullary growth pattern that display variable necrosis and lack peripheral lymphocytic infiltrate

• carnicomas contain pleomorphic cells with numerous mitotic figures such as lagging chromosomes

• neoplasms often invade in a broad front and push towards the underlying pectoral muscle

• a small minority of tumors have sqaumous characteristics

• pre-cancerous neoplasia are also evident throughout the mammary gland

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
breast cancer		DOID:1612	OMIM:114480	J:134977

Allelic Composition	Brca1^tm1Thl/Brca1^tm2Rjbr Kras^tm4Tyj/Kras⁺ Trp53^tm1Thl/Trp53^tm1Thl Tg(Pdx1-cre)6Tuv/0
Genetic Background	involves: 129S4/SvJae * C57BL/6 * FVB/N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Brca1^tm1Thl mutation (1 available); any Brca1 mutation (114 available)
Brca1^tm2Rjbr mutation (1 available); any Brca1 mutation (114 available)
Kras^tm4Tyj mutation (9 available); any Kras mutation (84 available)
Tg(Pdx1-cre)6Tuv mutation (3 available)
Trp53^tm1Thl mutation (0 available); any Trp53 mutation (240 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

neoplasm

decreased tumor latency ( J:177853 )

• 45 days compared with 68 days in Kras^tm4Tyj/Kras⁺ Tg(Ipf1-cre)6Tuv Trp53^tm1Thl/Trp53^tm1Thl

• however, latency is similar to in Brca1^tm1Thl/Brca1^tm1Thl Kras^tm4Tyj/Kras⁺ Tg(Ipf1-cre)6Tuv Trp53^tm1Thl/Trp53^tm1Thl

Allelic Composition	Brca1^tm1Thl/Brca1^tm3.1Rjbr Kras^tm4Tyj/Kras⁺ Trp53^tm1Thl/Trp53^tm1Thl Tg(Pdx1-cre)6Tuv/0
Genetic Background	involves: 129S4/SvJae * C57BL/6 * FVB/N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Brca1^tm1Thl mutation (1 available); any Brca1 mutation (114 available)
Brca1^tm3.1Rjbr mutation (1 available); any Brca1 mutation (114 available)
Kras^tm4Tyj mutation (9 available); any Kras mutation (84 available)
Tg(Pdx1-cre)6Tuv mutation (3 available)
Trp53^tm1Thl mutation (0 available); any Trp53 mutation (240 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

neoplasm

decreased tumor latency ( J:177853 )

• as in Kras^tm4Tyj/Kras⁺ Tg(Ipf1-cre)6Tuv Trp53^tm1Thl/Trp53^tm1Thlmice succumb to pancreatic tumors with an average latency of 65 days

Allelic Composition	Brca1^tm1Thl/Brca1^tm1Thl Kras^tm4Tyj/Kras⁺ Trp53^tm1Thl/Trp53^tm1Thl Tg(Pdx1-cre)6Tuv/0
Genetic Background	involves: 129S4/SvJae * C57BL/6 * FVB/N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Brca1^tm1Thl mutation (1 available); any Brca1 mutation (114 available)
Kras^tm4Tyj mutation (9 available); any Kras mutation (84 available)
Tg(Pdx1-cre)6Tuv mutation (3 available)
Trp53^tm1Thl mutation (0 available); any Trp53 mutation (240 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

neoplasm

decreased tumor latency ( J:177853 )

• mice succumb to pancreatic tumors with an average latency of 68 days

Allelic Composition	Brca1^tm1Arge/Brca1^tm1Thl Wap^tm1(cre)Arge/0
Genetic Background	involves: 129S/SvEv * 129S1/Sv * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Brca1^tm1Arge mutation (0 available); any Brca1 mutation (114 available)
Brca1^tm1Thl mutation (1 available); any Brca1 mutation (114 available)
Wap^tm1(cre)Arge mutation (0 available); any Wap mutation (33 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

neoplasm

increased mammary adenocarcinoma incidence ( J:134977 )

• almost all female mice who have been pregnant at least once develop mammary tumors with a mean tumor free latency of 512 days

• majority of tumors are solid, do not express the estrogen receptor but are CK14 positive

• the majority of the tumors are Dunn type B adenocarcinomas with a medullary growth pattern that display variable necrosis and lack peripheral lymphocytic infiltrate

• carnicomas contain pleomorphic cells with numerous mitotic figures such as lagging chromosomes

• neoplasms often invade in a broad front and push towards the underlying pectoral muscle

• a small minority of tumors have sqaumous characteristics

• pre-cancerous neoplasia are also evident throughout the mammary gland

integument

increased mammary adenocarcinoma incidence ( J:134977 )

• almost all female mice who have been pregnant at least once develop mammary tumors with a mean tumor free latency of 512 days

• majority of tumors are solid, do not express the estrogen receptor but are CK14 positive

• the majority of the tumors are Dunn type B adenocarcinomas with a medullary growth pattern that display variable necrosis and lack peripheral lymphocytic infiltrate

• carnicomas contain pleomorphic cells with numerous mitotic figures such as lagging chromosomes

• neoplasms often invade in a broad front and push towards the underlying pectoral muscle

• a small minority of tumors have sqaumous characteristics

• pre-cancerous neoplasia are also evident throughout the mammary gland

endocrine/exocrine glands

increased mammary adenocarcinoma incidence ( J:134977 )

• almost all female mice who have been pregnant at least once develop mammary tumors with a mean tumor free latency of 512 days

• majority of tumors are solid, do not express the estrogen receptor but are CK14 positive

• the majority of the tumors are Dunn type B adenocarcinomas with a medullary growth pattern that display variable necrosis and lack peripheral lymphocytic infiltrate

• carnicomas contain pleomorphic cells with numerous mitotic figures such as lagging chromosomes

• neoplasms often invade in a broad front and push towards the underlying pectoral muscle

• a small minority of tumors have sqaumous characteristics

• pre-cancerous neoplasia are also evident throughout the mammary gland

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
breast cancer		DOID:1612	OMIM:114480	J:134977

Allelic Composition	Bard1^tm2Thl/Bard1^tm2Thl Brca1^tm1Thl/Brca1^tm1Thl Wap^tm1(cre)Arge/0
Genetic Background	involves: 129/Sv * 129S1/Sv * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bard1^tm2Thl mutation (0 available); any Bard1 mutation (55 available)
Brca1^tm1Thl mutation (1 available); any Brca1 mutation (114 available)
Wap^tm1(cre)Arge mutation (0 available); any Wap mutation (33 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

neoplasm

increased mammary adenocarcinoma incidence ( J:134977 )

• almost all female mice who have been pregnant at least once develop mammary tumors with a mean tumor free latency of 473 days

• majority of tumors are solid, do not express the estrogen receptor but are CK14 positive

• the majority of the tumors are Dunn type B adenocarcinomas with a medullary growth pattern that display variable necrosis and lack peripheral lymphocytic infiltrate

• carnicomas contain pleomorphic cells with numerous mitotic figures such as lagging chromosomes

• neoplasms often invade in a broad front and push towards the underlying pectoral muscle

• a small minority of tumors have sqaumous characteristics

• pre-cancerous neoplasia are also evident throughout the mammary gland

integument

increased mammary adenocarcinoma incidence ( J:134977 )

• almost all female mice who have been pregnant at least once develop mammary tumors with a mean tumor free latency of 473 days

• majority of tumors are solid, do not express the estrogen receptor but are CK14 positive

• the majority of the tumors are Dunn type B adenocarcinomas with a medullary growth pattern that display variable necrosis and lack peripheral lymphocytic infiltrate

• carnicomas contain pleomorphic cells with numerous mitotic figures such as lagging chromosomes

• neoplasms often invade in a broad front and push towards the underlying pectoral muscle

• a small minority of tumors have sqaumous characteristics

• pre-cancerous neoplasia are also evident throughout the mammary gland

endocrine/exocrine glands

increased mammary adenocarcinoma incidence ( J:134977 )

• almost all female mice who have been pregnant at least once develop mammary tumors with a mean tumor free latency of 473 days

• majority of tumors are solid, do not express the estrogen receptor but are CK14 positive

• the majority of the tumors are Dunn type B adenocarcinomas with a medullary growth pattern that display variable necrosis and lack peripheral lymphocytic infiltrate

• carnicomas contain pleomorphic cells with numerous mitotic figures such as lagging chromosomes

• neoplasms often invade in a broad front and push towards the underlying pectoral muscle

• a small minority of tumors have sqaumous characteristics

• pre-cancerous neoplasia are also evident throughout the mammary gland

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
breast cancer		DOID:1612	OMIM:114480	J:134977

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