All Phenotypes Bard1<tm2Thl> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Bard1^tm2Thl
targeted mutation 2, Thomas Ludwig
MGI:3790742

Summary

5 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Bard1^tm2Thl/Bard1^tm2Thl	involves: 129 * C57BL/6J	MGI:3805022
cn2	Bard1^tm1Thl/Bard1^tm2Thl Wap^tm1(cre)Arge/0	involves: 129S1/Sv * C57BL/6J	MGI:3805024
cn3	Bard1^tm2Thl/Bard1^tm2Thl Wap^tm1(cre)Arge/0	involves: 129/Sv * 129S1/Sv * C57BL/6J	MGI:3805029
cn4	Bard1^tm2Thl/Bard1^tm2Thl Brca1^tm1Thl/Brca1^tm1Thl Wap^tm1(cre)Arge/0	involves: 129/Sv * 129S1/Sv * C57BL/6J	MGI:3805035
cn5	Bard1^tm1Thl/Bard1^tm2Thl Tg(Hsp70-1-cre)1Arge/0	involves: 129/Sv * 129S1/Sv * C57BL/6J * CBA	MGI:3805023

Allelic Composition	Bard1^tm2Thl/Bard1^tm2Thl
Genetic Background	involves: 129 * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bard1^tm2Thl mutation (0 available); any Bard1 mutation (55 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

normal phenotype

no abnormal phenotype detected ( J:134977 )

• mice are healthy, fertile, and have a normal lifespan

Allelic Composition	Bard1^tm1Thl/Bard1^tm2Thl Wap^tm1(cre)Arge/0
Genetic Background	involves: 129S1/Sv * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bard1^tm1Thl mutation (0 available); any Bard1 mutation (55 available)
Bard1^tm2Thl mutation (0 available); any Bard1 mutation (55 available)
Wap^tm1(cre)Arge mutation (0 available); any Wap mutation (33 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

neoplasm

increased mammary adenocarcinoma incidence ( J:134977 )

• almost all female mice who have been pregnant at least once develop mammary tumors with a mean tumor free latency of 465 days

• majority of tumors are solid, do not express the estrogen receptor but are CK14 positive

• the majority of the tumors are Dunn type B adenocarcinomas with a medullary growth pattern that display variable necrosis and lack peripheral lymphocytic infiltrate

• carnicomas contain pleomorphic cells with numerous mitotic figures such as lagging chromosomes

• neoplasms often invade in a broad front and push towards the underlying pectoral muscle

• a small minority of tumors have sqaumous characteristics

• pre-cancerous neoplasia are also evident throughout the mammary gland

integument

increased mammary adenocarcinoma incidence ( J:134977 )

• almost all female mice who have been pregnant at least once develop mammary tumors with a mean tumor free latency of 465 days

• majority of tumors are solid, do not express the estrogen receptor but are CK14 positive

• the majority of the tumors are Dunn type B adenocarcinomas with a medullary growth pattern that display variable necrosis and lack peripheral lymphocytic infiltrate

• carnicomas contain pleomorphic cells with numerous mitotic figures such as lagging chromosomes

• neoplasms often invade in a broad front and push towards the underlying pectoral muscle

• a small minority of tumors have sqaumous characteristics

• pre-cancerous neoplasia are also evident throughout the mammary gland

endocrine/exocrine glands

increased mammary adenocarcinoma incidence ( J:134977 )

• almost all female mice who have been pregnant at least once develop mammary tumors with a mean tumor free latency of 465 days

• majority of tumors are solid, do not express the estrogen receptor but are CK14 positive

• the majority of the tumors are Dunn type B adenocarcinomas with a medullary growth pattern that display variable necrosis and lack peripheral lymphocytic infiltrate

• carnicomas contain pleomorphic cells with numerous mitotic figures such as lagging chromosomes

• neoplasms often invade in a broad front and push towards the underlying pectoral muscle

• a small minority of tumors have sqaumous characteristics

• pre-cancerous neoplasia are also evident throughout the mammary gland

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
breast cancer		DOID:1612	OMIM:114480	J:134977

Allelic Composition	Bard1^tm2Thl/Bard1^tm2Thl Wap^tm1(cre)Arge/0
Genetic Background	involves: 129/Sv * 129S1/Sv * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bard1^tm2Thl mutation (0 available); any Bard1 mutation (55 available)
Wap^tm1(cre)Arge mutation (0 available); any Wap mutation (33 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

neoplasm

increased mammary adenocarcinoma incidence ( J:134977 )

• almost all female mice who have been pregnant at least once develop mammary tumors with a mean tumor free latency of 465 days

• majority of tumors are solid, do not express the estrogen receptor but are CK14 positive

• the majority of the tumors are Dunn type B adenocarcinomas with a medullary growth pattern that display variable necrosis and lack peripheral lymphocytic infiltrate

• carnicomas contain pleomorphic cells with numerous mitotic figures such as lagging chromosomes

• neoplasms often invade in a broad front and push towards the underlying pectoral muscle

• a small minority of tumors have sqaumous characteristics

• pre-cancerous neoplasia are also evident throughout the mammary gland

endocrine/exocrine glands

increased mammary adenocarcinoma incidence ( J:134977 )

• almost all female mice who have been pregnant at least once develop mammary tumors with a mean tumor free latency of 465 days

• majority of tumors are solid, do not express the estrogen receptor but are CK14 positive

• the majority of the tumors are Dunn type B adenocarcinomas with a medullary growth pattern that display variable necrosis and lack peripheral lymphocytic infiltrate

• carnicomas contain pleomorphic cells with numerous mitotic figures such as lagging chromosomes

• neoplasms often invade in a broad front and push towards the underlying pectoral muscle

• a small minority of tumors have sqaumous characteristics

• pre-cancerous neoplasia are also evident throughout the mammary gland

integument

increased mammary adenocarcinoma incidence ( J:134977 )

• almost all female mice who have been pregnant at least once develop mammary tumors with a mean tumor free latency of 465 days

• majority of tumors are solid, do not express the estrogen receptor but are CK14 positive

• the majority of the tumors are Dunn type B adenocarcinomas with a medullary growth pattern that display variable necrosis and lack peripheral lymphocytic infiltrate

• carnicomas contain pleomorphic cells with numerous mitotic figures such as lagging chromosomes

• neoplasms often invade in a broad front and push towards the underlying pectoral muscle

• a small minority of tumors have sqaumous characteristics

• pre-cancerous neoplasia are also evident throughout the mammary gland

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
breast cancer		DOID:1612	OMIM:114480	J:134977

Allelic Composition	Bard1^tm2Thl/Bard1^tm2Thl Brca1^tm1Thl/Brca1^tm1Thl Wap^tm1(cre)Arge/0
Genetic Background	involves: 129/Sv * 129S1/Sv * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bard1^tm2Thl mutation (0 available); any Bard1 mutation (55 available)
Brca1^tm1Thl mutation (1 available); any Brca1 mutation (114 available)
Wap^tm1(cre)Arge mutation (0 available); any Wap mutation (33 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

neoplasm

increased mammary adenocarcinoma incidence ( J:134977 )

• almost all female mice who have been pregnant at least once develop mammary tumors with a mean tumor free latency of 473 days

• majority of tumors are solid, do not express the estrogen receptor but are CK14 positive

• the majority of the tumors are Dunn type B adenocarcinomas with a medullary growth pattern that display variable necrosis and lack peripheral lymphocytic infiltrate

• carnicomas contain pleomorphic cells with numerous mitotic figures such as lagging chromosomes

• neoplasms often invade in a broad front and push towards the underlying pectoral muscle

• a small minority of tumors have sqaumous characteristics

• pre-cancerous neoplasia are also evident throughout the mammary gland

integument

increased mammary adenocarcinoma incidence ( J:134977 )

• almost all female mice who have been pregnant at least once develop mammary tumors with a mean tumor free latency of 473 days

• majority of tumors are solid, do not express the estrogen receptor but are CK14 positive

• the majority of the tumors are Dunn type B adenocarcinomas with a medullary growth pattern that display variable necrosis and lack peripheral lymphocytic infiltrate

• carnicomas contain pleomorphic cells with numerous mitotic figures such as lagging chromosomes

• neoplasms often invade in a broad front and push towards the underlying pectoral muscle

• a small minority of tumors have sqaumous characteristics

• pre-cancerous neoplasia are also evident throughout the mammary gland

endocrine/exocrine glands

increased mammary adenocarcinoma incidence ( J:134977 )

• almost all female mice who have been pregnant at least once develop mammary tumors with a mean tumor free latency of 473 days

• majority of tumors are solid, do not express the estrogen receptor but are CK14 positive

• the majority of the tumors are Dunn type B adenocarcinomas with a medullary growth pattern that display variable necrosis and lack peripheral lymphocytic infiltrate

• carnicomas contain pleomorphic cells with numerous mitotic figures such as lagging chromosomes

• neoplasms often invade in a broad front and push towards the underlying pectoral muscle

• a small minority of tumors have sqaumous characteristics

• pre-cancerous neoplasia are also evident throughout the mammary gland

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
breast cancer		DOID:1612	OMIM:114480	J:134977

Allelic Composition	Bard1^tm1Thl/Bard1^tm2Thl Tg(Hsp70-1-cre)1Arge/0
Genetic Background	involves: 129/Sv * 129S1/Sv * C57BL/6J * CBA

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

embryonic lethality, complete penetrance ( J:134977 )

• lethality occurs early in embryonic development

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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