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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Bdkrb1tm2Bdr
targeted mutation 2, Michael Bader
MGI:3790746
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
cx1
 		Bdkrb1tm2Bdr/Bdkrb1tm2Bdr
Bdkrb2tm1Jfh/Bdkrb2tm1Jfh 		involves: 129S7/SvEvBrd * C57BL/6 MGI:3797826


Genotype
MGI:3797826
cx1
Allelic
Composition		 Bdkrb1tm2Bdr/Bdkrb1tm2Bdr
Bdkrb2tm1Jfh/Bdkrb2tm1Jfh
Genetic
Background		 involves: 129S7/SvEvBrd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bdkrb1tm2Bdr mutation (0 available); any Bdkrb1 mutation (22 available)
Bdkrb2tm1Jfh mutation (3 available); any Bdkrb2 mutation (26 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
homeostasis/metabolism
decreased physiological sensitivity to xenobiotic ( J:135789 )
• several tissues (stomach, ileum, urinary bladder, uterus, aorta and portal vein) fail to exhibit contractile response to treatment with DABK and BK unlike wild-type mice

cardiovascular system
cardiovascular system phenotype ( J:135789 )
N
• blood pressure and cardiac morphology are normal

immune system
decreased susceptibility to endotoxin shock ( J:135789 )
• mice exhibit no hypotensive response to LPS unlike wild-type mice
• however, survival is the same as in wild-type mice following treatment with LPS




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory