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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Mfap2tm1Mech
targeted mutation 1, Robert P Mecham
MGI:3790750
Summary 4 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Mfap2tm1Mech/Mfap2tm1Mech B6.129X1-Mfap2tm1Mech MGI:3790758
hm2
 		Mfap2tm1Mech/Mfap2tm1Mech involves: 129X1/SvJ MGI:5551610
ht3
 		Mfap2tm1Mech/Mfap2+ B6.129X1-Mfap2tm1Mech MGI:3790759
cx4
 		Mfap2tm1Mech/Mfap2tm1Mech
Mfap5tm1Mech/Mfap5tm1Mech 		involves: 129X1/SvJ MGI:5551611


Genotype
MGI:3790758
hm1
Allelic
Composition		 Mfap2tm1Mech/Mfap2tm1Mech
Genetic
Background		 B6.129X1-Mfap2tm1Mech
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mfap2tm1Mech mutation (0 available); any Mfap2 mutation (14 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
thrombocytopenia ( J:134343 )
• mice have significantly lower number of platelets in circulation (770 x 109/L) than in littermate controls (1020 x 109/L)

homeostasis/metabolism
decreased susceptibility to induced thrombosis ( J:134343 )
• mice have a delayed occlusion time of 99 minutes after photochemical injury of the common carotid artery compared to 57 minutes for wild-type controls
• large, irregular spikes in carotid artery blood flow are observed after injury compared to the linear drop in flow that occurs in wild-type controls
increased bleeding time ( J:134343 )
• mean bleeding time from the tail vein (150 seconds) is almost twice that of their littermate controls (81 seconds)




Genotype
MGI:5551610
hm2
Allelic
Composition		 Mfap2tm1Mech/Mfap2tm1Mech
Genetic
Background		 involves: 129X1/SvJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mfap2tm1Mech mutation (0 available); any Mfap2 mutation (14 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system

cardiovascular system
cardiovascular system phenotype ( J:203960 )
N
• mice exhibit normal blood pressure and heart weight

hematopoietic system




Genotype
MGI:3790759
ht3
Allelic
Composition		 Mfap2tm1Mech/Mfap2+
Genetic
Background		 B6.129X1-Mfap2tm1Mech
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mfap2tm1Mech mutation (0 available); any Mfap2 mutation (14 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
homeostasis/metabolism
decreased susceptibility to induced thrombosis ( J:134343 )
• mice have a delayed occlusion time of 73 minutes after photochemical injury of the common carotid artery compared to 57 minutes for wild-type controls




Genotype
MGI:5551611
cx4
Allelic
Composition		 Mfap2tm1Mech/Mfap2tm1Mech
Mfap5tm1Mech/Mfap5tm1Mech
Genetic
Background		 involves: 129X1/SvJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mfap2tm1Mech mutation (0 available); any Mfap2 mutation (14 available)
Mfap5tm1Mech mutation (0 available); any Mfap5 mutation (16 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
skeleton
abnormal compact bone morphology ( J:203960 )
• reduced medullary volume
abnormal compact bone volume ( J:203960 )
• increased bone volume fraction in cortical bone due to reduced marrow cavity

immune system
immune system phenotype ( J:203960 )
N
• mice exhibit normal macrophage counts

cardiovascular system
cardiovascular system phenotype ( J:203960 )
N
• mice exhibit normal blood pressure and heart weight
abnormal aorta morphology ( J:203960 )
• increased outer diameter at physiological pressures at 6 months

hematopoietic system




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory