Phenotypes associated with this allele

• Allele Symbol: Hbb^{tm3(HBG1,HBB)Tow}
• Allele Name: targeted mutation 3, Timothy Townes
• Allele ID: MGI:3790756
• Summary: 4 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cx1	Hba^tm1(HBA)Tow/Hba^tm1(HBA)Tow Hbb^tm2(HBG1,HBB*)Tow/Hbb^tm3(HBG1,HBB)Tow Slc12a4^Rbc10/Slc12a4^Rbc10	involves: 129 * BALB/c * C57BL/6J	MGI:5896638
cx2	Hba^tm1(HBA)Tow/Hba^tm1(HBA)Tow Hbb^tm2(HBG1,HBB*)Tow/Hbb^tm3(HBG1,HBB)Tow	Not Specified	MGI:3803708
cx3	Hba^tm1(HBA)Tow/Hba^tm1(HBA)Tow Hbb^tm3(HBG1,HBB)Tow/Hbb^tm3(HBG1,HBB)Tow	Not Specified	MGI:3803751
cx4	Hba^tm1(HBA)Tow/Hba^tm1(HBA)Tow Hbb^tm2(HBG1,HBD,HBB*)Ryan/Hbb^tm3(HBG1,HBB)Tow	Not Specified	MGI:3846168

Genotype
MGI:5896638

cx1

• Allelic Composition: Hba^tm1(HBA)Tow/Hba^tm1(HBA)Tow; Hbb^{tm2(HBG1,HBB*)Tow}/Hbb^{tm3(HBG1,HBB)Tow}; Slc12a4^Rbc10/Slc12a4^Rbc10
• Genetic Background: involves: 129 * BALB/c * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

hematopoietic system

microcytic anemia ( J:227339 )

• increased anemia compared to mutant mice wild-type for Slc12a4

Genotype
MGI:3803708

cx2

• Allelic Composition: Hba^tm1(HBA)Tow/Hba^tm1(HBA)Tow; Hbb^{tm2(HBG1,HBB*)Tow}/Hbb^{tm3(HBG1,HBB)Tow}
• Genetic Background: Not Specified

hematopoietic system

hematopoietic system phenotype ( J:134980 )

N • red blood cell morphology, hematological parameters, and spleen size and morphology are all similar to controls and no extramedullary hematopoiesis is detected unlike mice homozygous for Hbb^{tm2(HBG1,HBB*)Tow}

anemia ( J:137709 )

• slightly thalassemic

liver/biliary system

liver/biliary system phenotype ( J:134980 )

N • liver morphology is similar to controls

renal/urinary system

renal/urinary system phenotype ( J:134980 )

N • kidney morphology and physiology are similar to controls

Genotype
MGI:3803751

cx3

• Allelic Composition: Hba^tm1(HBA)Tow/Hba^tm1(HBA)Tow; Hbb^{tm3(HBG1,HBB)Tow}/Hbb^{tm3(HBG1,HBB)Tow}
• Genetic Background: Not Specified

hematopoietic system

anemia ( J:137709 )

• slightly thalassemic

Genotype
MGI:3846168

cx4

• Allelic Composition: Hba^tm1(HBA)Tow/Hba^tm1(HBA)Tow; Hbb^{tm2(HBG1,HBD,HBB*)Ryan}/Hbb^{tm3(HBG1,HBB)Tow}
• Genetic Background: Not Specified

immune system

spleen hyperplasia ( J:148521 )

• spleen as a percentage of bodyweight is slightly increased

hematopoietic system

spleen hyperplasia ( J:148521 )

• spleen as a percentage of bodyweight is slightly increased

abnormal definitive hematopoiesis ( J:148521 )

• hemoglobin proteins are all of human origin

• at birth, blood contains 64% of human gamma globin chains and 36% human beta globin chains

• human beta-globin chain usage increases with age while gamma globin usage drops

• by 8 weeks of age beta-globin usage stabilizes at about 90% while delta and gamma chains make up about 5%

high mean erythrocyte cell number ( J:148521 )

• red blood cell count is about 10% higher than controls

decreased hemoglobin content ( J:148521 )

• hemoglobin content is decreased about 10%

decreased mean corpuscular volume ( J:148521 )

• packed cell volume is slightly decreased

reticulocytosis ( J:148521 )

• percentage of reticulocytes in the blood is increased

growth/size/body

spleen hyperplasia ( J:148521 )

• spleen as a percentage of bodyweight is slightly increased

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
beta thalassemia		DOID:12241	OMIM:613985	J:148521