Phenotypes associated with this allele

• Allele Symbol: Enpp2^tm1.1Vart
• Allele Name: targeted mutation 1.1, Vassilis Aidinis
• Allele ID: MGI:3790757
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Enpp2^tm1.1Vart/Enpp2^tm1.1Vart	B6.Cg-Enpp2^tm1.1Vart/Flmg	MGI:3790765
cx2	Enpp2^tm1.1Vart/Enpp2^tm1.1Vart Sox1^tm2Vep/Sox1^+	involves: C57BL/6	MGI:4441464

Genotype
MGI:3790765

hm1

• Allelic Composition: Enpp2^tm1.1Vart/Enpp2^tm1.1Vart
• Genetic Background: B6.Cg-Enpp2^tm1.1Vart/Flmg

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:134373 , J:159118 )

• homozygous mutant embryos die between E9.5 and E10.5 (J:134373)

• at E10.5, a large number of embryos are resorbed and remaining embryos are necrotic (J:159118)

embryo

abnormal vitelline vasculature morphology ( J:159118 )

• yolk sac vessels are enlarged compared to in wild-type mice

failure of initiation of embryo turning ( J:159118 )

• at E9.5

embryonic growth retardation ( J:159118 )

• at E9.5

abnormal neural tube morphology ( J:134373 , J:159118 )

• homozygous mutant embryos exhibit neural tube defects (J:134373)

• at E9.5, neural tube cells exhibit a decrease in cell proliferation and an increase in apoptosis compared to in wild-type mice (J:159118)

• however, dorsal-ventral patterning is normal (J:159118)

open neural tube ( J:159118 )

• at E9.5

abnormal somite development ( J:159118 )

• at E9.5, somitic pairs are reduced compared to in wild-type mice

abnormal trophoblast giant cell morphology ( J:159118 )

• trophoblast giant cells exhibit degeneration unlike in wild-type mice

abnormal allantois morphology ( J:159118 )

• allantoic blood vessels fail to spread through the decidual zone unlike in wild-type mice

abnormal chorionic plate morphology ( J:159118 )

• chorionic plate cells exhibit degeneration unlike in wild-type mice

failure of chorioallantoic fusion ( J:159118 )

cardiovascular system

abnormal blood vessel morphology ( J:159118 )

• enlarged blood vessels in the cephalic region

abnormal vasculogenesis ( J:134373 )

• homozygous mutant embryos exhibit defects of vasculogenesis

abnormal vitelline vasculature morphology ( J:159118 )

• yolk sac vessels are enlarged compared to in wild-type mice

abnormal blood circulation ( J:159118 )

• embryos exhibit circulatory failure unlike wild-type embryos

irregular heartbeat ( J:159118 )

• at E9.5

cellular

increased neural tube apoptosis ( J:159118 )

• at E9.5, neural tube cells exhibit an increase in apoptosis compared to in wild-type mice

abnormal axon extension ( J:159118 )

• neurite outgrowth from cultured cells of the somitic part of the E8.5 embryo trunk is reduced compared to neurite outgrowth of similarly treated cells from wild-type mice

decreased cell proliferation ( J:159118 )

• at E9.5, neural tube cells exhibit a decrease in cell proliferation and an increase in apoptosis compared to in wild-type mice

• cultured cells from the somitic part of the E8.5 embryo trunk exhibit reduced proliferation in culture compared with similarly treated cells from wild-type mice

nervous system

increased neural tube apoptosis ( J:159118 )

• at E9.5, neural tube cells exhibit an increase in apoptosis compared to in wild-type mice

abnormal axon extension ( J:159118 )

• neurite outgrowth from cultured cells of the somitic part of the E8.5 embryo trunk is reduced compared to neurite outgrowth of similarly treated cells from wild-type mice

abnormal neural tube morphology ( J:134373 , J:159118 )

• homozygous mutant embryos exhibit neural tube defects (J:134373)

• at E9.5, neural tube cells exhibit a decrease in cell proliferation and an increase in apoptosis compared to in wild-type mice (J:159118)

• however, dorsal-ventral patterning is normal (J:159118)

open neural tube ( J:159118 )

• at E9.5

growth/size/body

embryonic growth retardation ( J:159118 )

• at E9.5

Genotype
MGI:4441464

cx2

• Allelic Composition: Enpp2^tm1.1Vart/Enpp2^tm1.1Vart; Sox1^tm2Vep/Sox1⁺
• Genetic Background: involves: C57BL/6

embryo

abnormal neural tube morphology ( J:159118 )

• at E9.5, head folds are asymmetric unlike in wild-type mice

open neural tube ( J:159118 )

• at E9.5

kinked neural tube ( J:159118 )

• at E9.5

nervous system

abnormal neural tube morphology ( J:159118 )

• at E9.5, head folds are asymmetric unlike in wild-type mice

open neural tube ( J:159118 )

• at E9.5

kinked neural tube ( J:159118 )

• at E9.5