Analysis Tools
immune system
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• cells are absent from spleen
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• mice resist development of spontaneous diabetes compared to wild-type NOD controls
• when splenocytes from diabetic donors are transferred into lethally-irradiated 8-week old recipients, female mice remain normoglycemic for 14 weeks before developing hyperglycemia/diabetes; kinetics of disease development are much slower than wild-type recipients which maintain normoglycemia for <5 weeks post-transfer
• adoptive transfer of splenocytes from TCR-AI4 transgenic mice does not result in rapid disease development in contrast to wild-type controls
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hematopoietic system
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• cells are absent from spleen
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