Analysis Tools
immune system
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• there is slight increase in T-1 and T-2 transitional B cells in the spleen
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• in germinal center B cells of the Peyer's patch, there is a 2.5 fold reduction in the somatic hypermutation rate of the intron located downstream of the J-kappa exon
• the percentage of clones containing Ig-kappa genes with no mutations is 43% compared to only 25% of wild-type clones with no mutations
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• there is a 2-fold increase in the percentage of splenic B cells expressing Ig-lambda light chains
• there is a moderate decrease in the percentage of splenic B cells expressing Ig-kappa light chains (43%, down from 48% in wild-type mice)
• this decrease in Ig-kappa expression is partially due to decrease levels of Ig-kappa mRNA
• the Igkappa/lambda ratio of B cells in the spleen is 8.1-to-1 compared to the 17.1-to-1 ratio that is observed in wild-type mice
• the surface expression of Ig-kappa is slightly reduced on IgM positive B cells in the spleen
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• there is a slight decrease in follicular mature B cells in the spleen
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• sera levels of immunoglobulins containing kappa light chains are decreased compared to wild-type mice (15.3 mg/ml vs 6.7 mg/ml)
• there is a corresponding increase in sera Ig-lambda levels with a mean 1.46 mg/ml level observed compared to 0.91 mg/ml in wild-type mice
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hematopoietic system
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• there is slight increase in T-1 and T-2 transitional B cells in the spleen
|
|
• in germinal center B cells of the Peyer's patch, there is a 2.5 fold reduction in the somatic hypermutation rate of the intron located downstream of the J-kappa exon
• the percentage of clones containing Ig-kappa genes with no mutations is 43% compared to only 25% of wild-type clones with no mutations
|
|
• there is a 2-fold increase in the percentage of splenic B cells expressing Ig-lambda light chains
• there is a moderate decrease in the percentage of splenic B cells expressing Ig-kappa light chains (43%, down from 48% in wild-type mice)
• this decrease in Ig-kappa expression is partially due to decrease levels of Ig-kappa mRNA
• the Igkappa/lambda ratio of B cells in the spleen is 8.1-to-1 compared to the 17.1-to-1 ratio that is observed in wild-type mice
• the surface expression of Ig-kappa is slightly reduced on IgM positive B cells in the spleen
|
|
• there is a slight decrease in follicular mature B cells in the spleen
|
|
• sera levels of immunoglobulins containing kappa light chains are decreased compared to wild-type mice (15.3 mg/ml vs 6.7 mg/ml)
• there is a corresponding increase in sera Ig-lambda levels with a mean 1.46 mg/ml level observed compared to 0.91 mg/ml in wild-type mice
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