About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Plxnb1tm1.1Ltam
targeted mutation 1.1, Luca Tamagnone
MGI:3790773
Summary 5 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Plxnb1tm1.1Ltam/Plxnb1tm1.1Ltam involves: 129S1/Sv * C57BL/6 MGI:3805512
cx2
 		Plxnb1tm1.1Ltam/Plxnb1+
Plxnb2tm1Matl/Plxnb2+ 		involves: 129P2/OlaHsd * 129S1/Sv * C57BL/6 MGI:5811331
cx3
 		Plxnb1tm1.1Ltam/Plxnb1tm1.1Ltam
Plxnb2tm1Matl/Plxnb2+ 		involves: 129P2/OlaHsd * 129S1/Sv * C57BL/6 MGI:5811335
cx4
 		Plxnb1tm1.1Ltam/Plxnb1+
Plxnb2tm1Matl/Plxnb2tm1Matl 		involves: 129P2/OlaHsd * 129S1/Sv * C57BL/6 MGI:5811340
cx5
 		Plxnb1tm1.1Ltam/Plxnb1tm1.1Ltam
Plxnb2tm1Matl/Plxnb2tm1Matl 		involves: 129P2/OlaHsd * 129S1/Sv * C57BL/6 MGI:5811341


Genotype
MGI:3805512
hm1
Allelic
Composition		 Plxnb1tm1.1Ltam/Plxnb1tm1.1Ltam
Genetic
Background		 involves: 129S1/Sv * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Plxnb1tm1.1Ltam mutation (2 available); any Plxnb1 mutation (108 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
renal/urinary system
enlarged kidney ( J:168399 )
• at E13.5, kidneys are larger than those in heterozygous controls
• however, no differences in size are detected at E11.5 and E12.5
abnormal branching involved in ureteric bud morphogenesis ( J:168399 )
• at E13.5, kidneys exhibit more ureteric branches than those in heterozygous controls
• however, no differences in developmental stage are detected at E11.5 and E12.5

normal phenotype
no abnormal phenotype detected ( J:134426 )
• viable and fertile, no defects in development, or in adult histology and basic functional parameters

growth/size/body
enlarged kidney ( J:168399 )
• at E13.5, kidneys are larger than those in heterozygous controls
• however, no differences in size are detected at E11.5 and E12.5




Genotype
MGI:5811331
cx2
Allelic
Composition		 Plxnb1tm1.1Ltam/Plxnb1+
Plxnb2tm1Matl/Plxnb2+
Genetic
Background		 involves: 129P2/OlaHsd * 129S1/Sv * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Plxnb1tm1.1Ltam mutation (2 available); any Plxnb1 mutation (108 available)
Plxnb2tm1Matl mutation (2 available); any Plxnb2 mutation (88 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
mortality/aging ( J:168399 )
N
• mice are viable

reproductive system
reduced fertility ( J:168399 )
• mice are able to produce offspring although litters are very small




Genotype
MGI:5811335
cx3
Allelic
Composition		 Plxnb1tm1.1Ltam/Plxnb1tm1.1Ltam
Plxnb2tm1Matl/Plxnb2+
Genetic
Background		 involves: 129P2/OlaHsd * 129S1/Sv * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Plxnb1tm1.1Ltam mutation (2 available); any Plxnb1 mutation (108 available)
Plxnb2tm1Matl mutation (2 available); any Plxnb2 mutation (88 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
mortality/aging ( J:168399 )
N
• mice are viable

reproductive system
reduced fertility ( J:168399 )
• mice are able to produce offspring although litters are very small




Genotype
MGI:5811340
cx4
Allelic
Composition		 Plxnb1tm1.1Ltam/Plxnb1+
Plxnb2tm1Matl/Plxnb2tm1Matl
Genetic
Background		 involves: 129P2/OlaHsd * 129S1/Sv * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Plxnb1tm1.1Ltam mutation (2 available); any Plxnb1 mutation (108 available)
Plxnb2tm1Matl mutation (2 available); any Plxnb2 mutation (88 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging




Genotype
MGI:5811341
cx5
Allelic
Composition		 Plxnb1tm1.1Ltam/Plxnb1tm1.1Ltam
Plxnb2tm1Matl/Plxnb2tm1Matl
Genetic
Background		 involves: 129P2/OlaHsd * 129S1/Sv * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Plxnb1tm1.1Ltam mutation (2 available); any Plxnb1 mutation (108 available)
Plxnb2tm1Matl mutation (2 available); any Plxnb2 mutation (88 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
embryonic lethality ( J:168399 )
• double homozygotes show high embryonic lethality prior to onset of nephrogenesis
• only 1 of 19 double homozygotes survived to E12.5

renal/urinary system
renal hypoplasia ( J:168399 )
• the single double homozygous embryo surviving to E12 showed hypoplastic kidneys with ureteric branches and differentiating mesenchyme
abnormal ureteric bud trunk morphology ( J:168399 )
• at E12, the ureteric stalks appear to be longer than in double heterozygotes




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory