Phenotypes associated with this allele

• Allele Symbol: Fgf16^tm1(cre)Sms
• Allele Name: targeted mutation 1, Suzanne L Mansour
• Allele ID: MGI:3790778
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Fgf16^tm1(cre)Sms/Fgf16^tm1(cre)Sms	involves: 129S1/Sv * 129X1/SvJ * C57BL/6	MGI:3810531
ot2	Fgf16^tm1(cre)Sms/Y	involves: 129S1/Sv * 129X1/SvJ	MGI:3810533

Genotype
MGI:3810531

hm1

• Allelic Composition: Fgf16^tm1(cre)Sms/Fgf16^tm1(cre)Sms
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

mortality/aging ( J:139718 )

♀N • at weaning, homozygous female pups are present in the expected Mendelian numbers/ratio among progeny of heterozygous female by hemizygous male mice

reproductive system

reproductive system phenotype ( J:139718 )

♀N • female mice homozygous for this mutation exhibit normal fertility

hearing/vestibular/ear

hearing/vestibular/ear phenotype ( J:139718 )

♀N • homozygous mutant female mice do not exhibit behaviors indicating vestibular dysfunction, e.g., circling or head bobbing/shaking

♀N • fixed, paint-filled inner ear structures of E15.5 homozygous female embryos exhibit no gross morphological abnormalities

behavior/neurological

behavior/neurological phenotype ( J:139718 )

♀N • homozygous mutant female mice do not exhibit behaviors indicating vestibular dysfunction, e.g., circling or head bobbing/shaking

Genotype
MGI:3810533

ot2

• Allelic Composition: Fgf16^tm1(cre)Sms/Y
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ

mortality/aging

mortality/aging ( J:139718 )

♂N • at weaning, hemizygous male pups are present at the expected Mendelian number/ratio among progeny of crosses between heterozygous female and hemizygous or wild-type male mice

reproductive system

reproductive system phenotype ( J:139718 )

♂N • male mice hemizygous for this mutation exhibit normal fertility

hearing/vestibular/ear

hearing/vestibular/ear phenotype ( J:139718 )

♂N • hemizygous mutant male mice do not exhibit behaviors indicating vestibular dysfunction, e.g., circling or head bobbing/shaking

♂N • the ABR thresholds of hemizygous mutant males do not differ significantly from those of control heterozygous and wild-type female mice, averaging 29 dB vs. 28 dB and 29 dB, respectively

♂N • fixed, paint-filled inner ear structures of E15.5 hemizygous male embryos exhibit no gross morphological abnormalities

behavior/neurological

behavior/neurological phenotype ( J:139718 )

♂N • hemizygous mutant male mice do not exhibit behaviors indicating vestibular dysfunction, e.g., circling or head bobbing/shaking