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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Nr1i2tm1(NR1I2)Arte
targeted mutation 1, TaconicArtemis
MGI:3790844
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Nr1i2tm1(NR1I2)Arte/Nr1i2tm1(NR1I2)Arte involves: C57BL/6 MGI:3815122
cx2
 		Abcc2tm1.1(ABCC2)Arte/Abcc2tm1.1(ABCC2)Arte
Nr1i2tm1(NR1I2)Arte/Nr1i2tm1(NR1I2)Arte 		involves: C57BL/6 MGI:5609259
cx3
 		Nr1i2tm1(NR1I2)Arte/Nr1i2tm1(NR1I2)Arte
Nr1i3tm1.1Arte/Nr1i3tm1.1Arte 		involves: C57BL/6NTac MGI:3815127


Genotype
MGI:3815122
hm1
Allelic
Composition		 Nr1i2tm1(NR1I2)Arte/Nr1i2tm1(NR1I2)Arte
Genetic
Background		 involves: C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nr1i2tm1(NR1I2)Arte mutation (2 available); any Nr1i2 mutation (35 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
mortality/aging ( J:140975 )
N
• mice exhibit normal survival

homeostasis/metabolism
decreased physiological sensitivity to xenobiotic ( J:140975 )
• mice exhibit decreased induction of Cyp3a11 expression following treatment with dexamethasone or clotrimazole than in similarly treated wild-type mice
• however, mice exhibit normal induction of Cyp2b10 expression following treatment with dexamethasone
increased physiological sensitivity to xenobiotic ( J:140975 )
• mice exhibit increased induction of Cyp3a11 expression at lower doses of RIF than in similarly treated wild-type mice
• however, mice do not exhibit induction of Cyp2b10 expression following treatment with RIF

liver/biliary system
liver/biliary system phenotype ( J:140975 )
N
• mice exhibit normal liver histology

reproductive system
reproductive system phenotype ( J:140975 )
N
• mice exhibit normal fertility




Genotype
MGI:5609259
cx2
Allelic
Composition		 Abcc2tm1.1(ABCC2)Arte/Abcc2tm1.1(ABCC2)Arte
Nr1i2tm1(NR1I2)Arte/Nr1i2tm1(NR1I2)Arte
Genetic
Background		 involves: C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Abcc2tm1.1(ABCC2)Arte mutation (0 available); any Abcc2 mutation (90 available)
Nr1i2tm1(NR1I2)Arte mutation (2 available); any Nr1i2 mutation (35 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
homeostasis/metabolism
homeostasis/metabolism phenotype ( J:216646 )
N
• plasma and urine bilirubin levels are similar to controls




Genotype
MGI:3815127
cx3
Allelic
Composition		 Nr1i2tm1(NR1I2)Arte/Nr1i2tm1(NR1I2)Arte
Nr1i3tm1.1Arte/Nr1i3tm1.1Arte
Genetic
Background		 involves: C57BL/6NTac
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nr1i2tm1(NR1I2)Arte mutation (2 available); any Nr1i2 mutation (35 available)
Nr1i3tm1.1Arte mutation (4 available); any Nr1i3 mutation (36 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
homeostasis/metabolism
decreased physiological sensitivity to xenobiotic ( J:140975 )
• mice fail to exhibit phenobarbital induced Cyp3a11 or Cyp2b10 expression




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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory