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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Mirc2tm1.1Tyj
targeted mutation 1.1, Tyler Jacks
MGI:3790966
Summary 5 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Mirc2tm1.1Tyj/Mirc2tm1.1Tyj involves: 129S4/SvJae * C57BL/6 * SJL MGI:3796134
cx2
 		Mirc2tm1.1Tyj/Y
Mirc3tm1.1Tyj/Mirc3tm1.1Tyj
Mirc1tm1.2Tyj/Mirc1tm1.2Tyj 		involves: 129S4/SvJae * C57BL/6 * FVB/N * SJL MGI:3796152
cx3
 		Mirc2tm1.1Tyj/Y
Mirc3tm1.1Tyj/Mirc3tm1.1Tyj
Mirc1tm1.2Tyj/Mirc1+ 		involves: 129S4/SvJae * C57BL/6 * FVB/N * SJL MGI:3796153
cx4
 		Mirc2tm1.1Tyj/Y
Mirc3tm1.1Tyj/Mirc3+
Mirc1tm1.2Tyj/Mirc1+ 		involves: 129S4/SvJae * C57BL/6 * FVB/N * SJL MGI:3796428
ot5
 		Mirc2tm1.1Tyj/Y involves: 129S4/SvJae * C57BL/6 * SJL MGI:3796422


Genotype
MGI:3796134
hm1
Allelic
Composition		 Mirc2tm1.1Tyj/Mirc2tm1.1Tyj
Genetic
Background		 involves: 129S4/SvJae * C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mirc2tm1.1Tyj mutation (1 available); any Mirc2 mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
normal phenotype
no abnormal phenotype detected ( J:134861 )
• mice are viable, reproduce normally, and display no obvious abnormal phenotype
• mice are indistinguishable from Mirn106a-363tm1Tyj homozygotes




Genotype
MGI:3796152
cx2
Allelic
Composition		 Mirc2tm1.1Tyj/Y
Mirc3tm1.1Tyj/Mirc3tm1.1Tyj
Mirc1tm1.2Tyj/Mirc1tm1.2Tyj
Genetic
Background		 involves: 129S4/SvJae * C57BL/6 * FVB/N * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mirc1tm1.2Tyj mutation (1 available); any Mirc1 mutation (6 available)
Mirc2tm1.1Tyj mutation (1 available); any Mirc2 mutation (1 available)
Mirc3tm1.1Tyj mutation (1 available); any Mirc3 mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
prenatal lethality, complete penetrance ( J:134861 )
• embryos die before E15

cardiovascular system
atrial septal defect ( J:134861 )
• defective atrial and ventricular septation at E13.5 and E14.5
ventricular septal defect ( J:134861 )
• defective atrial and ventricular septation at E13.5 and E14.5
thin ventricular wall ( J:134861 )
• ventricles are thinner than in wild-type at E13.5 and 14.5

cellular
increased apoptosis ( J:134861 )
• increased apoptosis is seen at E14.5 in fetal liver, ventral horns of spinal cord, and lateral ganglionic eminences




Genotype
MGI:3796153
cx3
Allelic
Composition		 Mirc2tm1.1Tyj/Y
Mirc3tm1.1Tyj/Mirc3tm1.1Tyj
Mirc1tm1.2Tyj/Mirc1+
Genetic
Background		 involves: 129S4/SvJae * C57BL/6 * FVB/N * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mirc1tm1.2Tyj mutation (1 available); any Mirc1 mutation (6 available)
Mirc2tm1.1Tyj mutation (1 available); any Mirc2 mutation (1 available)
Mirc3tm1.1Tyj mutation (1 available); any Mirc3 mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
normal phenotype
no abnormal phenotype detected ( J:134861 )
• mice are viable and fertile




Genotype
MGI:3796428
cx4
Allelic
Composition		 Mirc2tm1.1Tyj/Y
Mirc3tm1.1Tyj/Mirc3+
Mirc1tm1.2Tyj/Mirc1+
Genetic
Background		 involves: 129S4/SvJae * C57BL/6 * FVB/N * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mirc1tm1.2Tyj mutation (1 available); any Mirc1 mutation (6 available)
Mirc2tm1.1Tyj mutation (1 available); any Mirc2 mutation (1 available)
Mirc3tm1.1Tyj mutation (1 available); any Mirc3 mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
normal phenotype
no abnormal phenotype detected ( J:134861 )
• mice are viable and fertile




Genotype
MGI:3796422
ot5
Allelic
Composition		 Mirc2tm1.1Tyj/Y
Genetic
Background		 involves: 129S4/SvJae * C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mirc2tm1.1Tyj mutation (1 available); any Mirc2 mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
normal phenotype
no abnormal phenotype detected ( J:134861 )
• mice are viable, reproduce normally, and display no obvious abnormal phenotype
• mice are indistinguishable from Mirn106a-363tm1Tyj hemizygotes




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory